Prognostic significance of neutrophil-to-lymphocyte ratio in HPV status era for oropharyngeal cancer: Oral Diseases

G. Fanetti, D. Alterio, G. Marvaso, S. Gandini, D.P. Rojas, C. Gobitti, E. Minatel, A. Revelant, A. Caroli, C.M. Francia, O. Alessandro, M. Pepa, S.G. Gugliandolo, A. Starzyńska, J. Polesel, E. Vaccher, M. Cossu Rocca, M. Tagliabue, M. Ansarin, V. LupatoV. Giacomarra, A. De Paoli, R. Orecchia, G. Franchin, B.A. Jereczek-Fossa

Research output: Contribution to journalArticlepeer-review


Aim: To evaluate the role of baseline neutrophil-to-lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status. Patients and methods: A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression-free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed. Results: Seventy-seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow-up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two-year OS was 91% and 81% in pts with NLR
Original languageEnglish
Pages (from-to)1384-1392
Number of pages9
JournalOral Dis.
Issue number7
Publication statusPublished - 2020


  • biomarkers
  • HPV status
  • neutrophil-to-lymphocyte ratio
  • oropharyngeal cancer
  • radiotherapy
  • cetuximab
  • cisplatin
  • docetaxel
  • fluorouracil
  • hemoglobin
  • adult
  • aged
  • Article
  • cancer prognosis
  • cancer staging
  • chemoradiotherapy
  • clinical article
  • clinical outcome
  • drug megadose
  • female
  • follow up
  • hemoglobin blood level
  • human
  • induction chemotherapy
  • loading drug dose
  • male
  • neutrophil lymphocyte ratio
  • oropharynx squamous cell carcinoma
  • overall survival
  • papillomavirus infection
  • priority journal
  • progression free survival
  • retrospective study
  • complication
  • lymphocyte
  • neutrophil
  • oropharynx tumor
  • prognosis
  • Humans
  • Lymphocytes
  • Neutrophils
  • Oropharyngeal Neoplasms
  • Papillomavirus Infections
  • Prognosis
  • Retrospective Studies


Dive into the research topics of 'Prognostic significance of neutrophil-to-lymphocyte ratio in HPV status era for oropharyngeal cancer: Oral Diseases'. Together they form a unique fingerprint.

Cite this