Prognostic significance of presence and reduplication of basal lamina in malignant pleural mesothelioma

Marcello Di Muzio, Luciana Spoletini, Luigi Strizzi, Giovina Vianale, Vincenzo Fontana, Maria Antonietta Orengo, Gianfranco Tassi, Angelo Casalini, Luciano Mutti, Antonio Procopio

Research output: Contribution to journalArticlepeer-review

Abstract

The prognosis of patients with malignant pleural mesothelioma (MM) is dependent more on tumor extension and differentiation than on therapeutic effects. Reduplication of the basal lamina (RBL) is an ultrastructural feature of some benign and malignant tumors that has been inversely correlated with aggressiveness and was recently described in MM. To investigate whether RBL is important for predicting the survival of patients with MM, transmission electron microscopy was used to identify the presence of basal lamina or RBL in biopsy specimens obtained by thoracoscopy from 35 patients. Cox's regression analysis was used to study the relation of these ultrastructural features to survival. Better outcomes were found for patients whose tumors expressed either basal lamina (HR 0.48; 95% CI, 0.09-2.47) or RBL (HR 0.38; 95% CI 0.12-1.22) compared with the reference category, where basal lamina or RBL was not found. The expression of basal lamina and RBL is an important novel prognostic factors in MM. (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)1341-1345
Number of pages5
JournalHuman Pathology
Volume31
Issue number11
Publication statusPublished - 2000

Keywords

  • Basal lamina
  • Mesothelioma
  • Prognosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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