The value of prolactin receptor (PRLR) determination in predicting overall survival has been retrospectively evaluated in a group of 170 women bearing primary breast cancer stage I, II and IIIA. All patients underwent surgery (radical or modified mastectomy or quadrantectomy and axillary dissection followed by radiotherapy according to TNM stage) between January 1977 and December 1986. In all patients, oestrogen and progesterone receptors concentrations were also determined. Overall actuarial survival was higher in patients having PRLR positive tumours when compared to patients having PRLR negative tumours (p = 0.0126). No difference in survival was observed between oestrogen or progesterone receptor positive or negative patients. Using Cox's multivariate analysis on 164 patients, stage and PRLR status were the only significant prognostic factors affecting survival (p <0.0001, RR = 4.61 and p = 0.0130, RR = 0.53 respectively). From these results it appears that PRLR may be of prognostic value in patients with breast cancer.
ASJC Scopus subject areas
- Obstetrics and Gynaecology