Abstract
Background: Adipokines may significantly influence the growth and proliferation of tumor stroma and malignant cells within. Reduced adiponectin and increased leptin serum levels were found in colorectal cancer (CRC) patients. Recently, it has been demonstrated that tumor necrosis factor-α (TNF-α) is able to induce dose-dependent changes in serum adipokine levels. Thus, aims of this study were to evaluate the possible associations between adipokines, TNF-α and clinicopathological variables of CRC patients and to analyze their possible prognostic value in predicting relapse-free and overall survival. Materials and Methods: Baseline leptin, adiponectin and TNF-α levels were analyzed in 90 patients with histologically diagnosed primary or newly diagnosed metastatic CRC treated at 'Tor Vergata' Clinical Center and followed up for a median period of 3 years. Results: Serum leptin levels were higher in CRC patients than in controls (p
Original language | English |
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Pages (from-to) | 3321-3327 |
Number of pages | 7 |
Journal | Anticancer Research |
Volume | 29 |
Issue number | 8 |
Publication status | Published - Aug 2009 |
Keywords
- Adiponectin
- Colorectal cancer
- Leptin
- Prognosis
ASJC Scopus subject areas
- Cancer Research
- Oncology