Prognostic significance of serum adipokine levels in colorectal cancer patients

Fiorella Guadagni, Mario Roselli, Francesca Martini, Antonella Spila, Silvia Riondino, Roberta D'Alessandro, Girolamo Del Monte, Vincenzo Formica, Anastasia Laudisi, Ilaria Portarena, Raffaele Palmirotta, Patrizia Ferroni

Research output: Contribution to journalArticle

Abstract

Background: Adipokines may significantly influence the growth and proliferation of tumor stroma and malignant cells within. Reduced adiponectin and increased leptin serum levels were found in colorectal cancer (CRC) patients. Recently, it has been demonstrated that tumor necrosis factor-α (TNF-α) is able to induce dose-dependent changes in serum adipokine levels. Thus, aims of this study were to evaluate the possible associations between adipokines, TNF-α and clinicopathological variables of CRC patients and to analyze their possible prognostic value in predicting relapse-free and overall survival. Materials and Methods: Baseline leptin, adiponectin and TNF-α levels were analyzed in 90 patients with histologically diagnosed primary or newly diagnosed metastatic CRC treated at 'Tor Vergata' Clinical Center and followed up for a median period of 3 years. Results: Serum leptin levels were higher in CRC patients than in controls (p

Original languageEnglish
Pages (from-to)3321-3327
Number of pages7
JournalAnticancer Research
Volume29
Issue number8
Publication statusPublished - Aug 2009

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Keywords

  • Adiponectin
  • Colorectal cancer
  • Leptin
  • Prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Guadagni, F., Roselli, M., Martini, F., Spila, A., Riondino, S., D'Alessandro, R., Del Monte, G., Formica, V., Laudisi, A., Portarena, I., Palmirotta, R., & Ferroni, P. (2009). Prognostic significance of serum adipokine levels in colorectal cancer patients. Anticancer Research, 29(8), 3321-3327.