Prognostic significance of the CaMBr1 antigen on breast carcinoma: Relevance of the type of recognised glycoconjugate

F. Perrone, S. Ménard, S. Canevari, M. Calabrese, P. Boracchi, R. Bufalino, S. Testori, M. Baldini, M. I. Colnaghi

Research output: Contribution to journalArticlepeer-review

Abstract

An extensive study of the expression of the blood group-related antigen CaMBr1 has been performed by immunohistochemistry, immunoblotting and high performance thin layer chromatography both on frozen and paraffin-embedded (paraffin) samples from normal and neoplastic breast tissues. The glycolipid antigenic fraction (from frozen samples) was preferentially expressed on functioning breast epithelium. In a prospective series of 143 breast cancer cases CaMBr1 expression was associated, on frozen sections, with the transferrin receptor (P = 0.01), the positivity with oestrogen receptor immunochemical assay (P = 0.06), premenopausal status (P = 0.06) and node negativity (P = 0.07). Non-significant correlation with longer disease-free survival (DFS) was observed. In a retrospective series of 862 cases on paraffin sections the glycoproteic antigenic fraction was significantly associated with premenopausal status (P <0.05) and lobular histotype (P <0.01), but failed to predict survival, although a trend for longer DFS was observed for positive cases.

Original languageEnglish
Pages (from-to)2113-2117
Number of pages5
JournalEuropean Journal of Cancer
Volume29
Issue number15
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Fingerprint

Dive into the research topics of 'Prognostic significance of the CaMBr1 antigen on breast carcinoma: Relevance of the type of recognised glycoconjugate'. Together they form a unique fingerprint.

Cite this