Prognostic significance of the growth rate of breast cancer

Preliminary evaluation on the follow-up of 196 breast cancers

E. Galante, A. Guzzon, G. Gallus, M. Mauri, A. Bono, A. De Carli, M. Merson, S. Di Pietro

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Abstract

The doubling time (DT) of 196 consecutive breast cancers was studied by means of a double mammographic examination (average time between the 2 mammographies, 30 days) and calculated with the formula of exponential growth. On the basis of DT values, the case series was divided into 3 groups of growth: fast (DT from 1 to 30 days), 31 cases (15.8%); intermediate (DT from 31 to 90 days), 84 cases (42.9%); and slow (DT more than 90 days), 81 cases (41.3%). No relationship was found between the growth rate and the size of tumor, or menopausal status of the patient. After mastectomy, the fast and slow cases were equally distributed in the N- and N+ groups, whereas for the intermediate cases the N-:N+ ratio was 1:2. 134 cases were followed for a period of 12 to 52 months. Evaluation was done on the basis of the subdivision into N- and N+, and the latter group into N+ (1-3) and N+ (>3). For N- tumors, the course of the disease was apparently not affected by the growth rate. However, the case of fast growing tumors showed a higher proportion of recurrences with respect to N+ slow growing tumors. This difference was even more noticeable the higher the number of involved lymph nodes, but not statistically significant. The course of slow growing tumors was identical in the N- and N+ groups, but all the N+ tumors were subjected to adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)333-340
Number of pages8
JournalTumori
Volume67
Issue number4
Publication statusPublished - 1981

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Breast Neoplasms
Growth
Neoplasms
Mastectomy
Mammography
Adjuvant Chemotherapy
Lymph Nodes
Recurrence

ASJC Scopus subject areas

  • Cancer Research

Cite this

Galante, E., Guzzon, A., Gallus, G., Mauri, M., Bono, A., De Carli, A., ... Di Pietro, S. (1981). Prognostic significance of the growth rate of breast cancer: Preliminary evaluation on the follow-up of 196 breast cancers. Tumori, 67(4), 333-340.

Prognostic significance of the growth rate of breast cancer : Preliminary evaluation on the follow-up of 196 breast cancers. / Galante, E.; Guzzon, A.; Gallus, G.; Mauri, M.; Bono, A.; De Carli, A.; Merson, M.; Di Pietro, S.

In: Tumori, Vol. 67, No. 4, 1981, p. 333-340.

Research output: Contribution to journalArticle

Galante, E, Guzzon, A, Gallus, G, Mauri, M, Bono, A, De Carli, A, Merson, M & Di Pietro, S 1981, 'Prognostic significance of the growth rate of breast cancer: Preliminary evaluation on the follow-up of 196 breast cancers', Tumori, vol. 67, no. 4, pp. 333-340.
Galante, E. ; Guzzon, A. ; Gallus, G. ; Mauri, M. ; Bono, A. ; De Carli, A. ; Merson, M. ; Di Pietro, S. / Prognostic significance of the growth rate of breast cancer : Preliminary evaluation on the follow-up of 196 breast cancers. In: Tumori. 1981 ; Vol. 67, No. 4. pp. 333-340.
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