Prognostic significance of tumor grade in clinical trials of adjuvant therapy for breast cancer with axillary lymph node metastasis

B. W. Davis, R. D. Gelber, A. Goldhirsch, W. H. Hartmann, G. W. Locher, R. Reed, R. Golouh, J. Säve-Söderbergh, L. Holloway, I. Russell

Research output: Contribution to journalArticlepeer-review

Abstract

The prognostic significance of histologic tumor grade has been evaluated in 1537 women entered into the Ludwig Trials I-IV of adjuvant therapy for node-positive breast cancer. Tumor grade was determined on histologic review of primary tumor sections by two central review pathologists using a modification of the Bloom and Richardson grading system. The 5-year overall survival rates (±SE) were: Grade 1,86% ± 2; Grade 2, 70% ± 2; and Grade 3, 57% ± 2 (P

Original languageEnglish
Pages (from-to)2662-2670
Number of pages9
JournalCancer
Volume58
Issue number12
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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