Prognostic stratification of patients with ST-segment-elevation myocardial infarction (PROSPECT): A cardiac magnetic resonance study

G. Pontone, A.I. Guaricci, D. Andreini, G. Ferro, M. Guglielmo, A. Baggiano, L. Fusini, G. Muscogiuri, V. Lorenzoni, S. Mushtaq, E. Conte, A. Annoni, A. Formenti, M.E. Mancini, P. Carità, M. Verdecchia, S. Pica, F. Fazzari, N. Cosentino, G. MarenziM.G. Rabbat, P. Agostoni, A.L. Bartorelli, M. Pepi, P.G. Masci

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background-Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment-elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement. Methods and Results-Two hundred nine consecutive patients with ST-segment-elevation myocardial infarction (age, 61.4±11.4 years; 162 men) underwent transthoracic echocardiography and CMR after succesful primary percutaneous coronary intervention. Major adverse cardiac events (MACE) were assessed at a mean follow-up of 2.5±1.2 years. MACE occurred in 24 (12%) patients who at baseline showed higher GRACE risk score (P
Original languageEnglish
JournalCirculation: Cardiovascular Imaging
Volume10
Issue number11
DOIs
Publication statusPublished - 2017

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Magnetic Resonance Spectroscopy
Stroke Volume
Registries
Echocardiography
Percutaneous Coronary Intervention
Hemorrhage
ST Elevation Myocardial Infarction

Keywords

  • Humans
  • Magnetic resonance
  • Prognosis
  • ST-segment-elevation myocardial infarction
  • gadobenate dimeglumine
  • gadobenic acid
  • adult
  • Article
  • blood vessel occlusion
  • cardiovascular magnetic resonance
  • controlled study
  • coronary angiography
  • female
  • heart left ventricle ejection fraction
  • heart left ventricle mass
  • human
  • major adverse cardiac event
  • major clinical study
  • male
  • middle aged
  • myocardial hemorrhage
  • myocardial salvage index
  • percutaneous coronary intervention
  • priority journal
  • ST segment elevation myocardial infarction
  • transthoracic echocardiography
  • aged
  • bleeding
  • chi square distribution
  • cine magnetic resonance imaging
  • comparative study
  • coronary artery blood flow
  • diagnostic imaging
  • echocardiography
  • heart left ventricle function
  • heart stroke volume
  • microcirculation
  • multivariate analysis
  • pathophysiology
  • predictive value
  • proportional hazards model
  • risk factor
  • time factor
  • treatment outcome
  • Aged
  • Chi-Square Distribution
  • Coronary Angiography
  • Coronary Circulation
  • Echocardiography
  • Female
  • Hemorrhage
  • Magnetic Resonance Imaging, Cine
  • Male
  • Microcirculation
  • Middle Aged
  • Multivariate Analysis
  • Percutaneous Coronary Intervention
  • Predictive Value of Tests
  • Proportional Hazards Models
  • Risk Factors
  • ST Elevation Myocardial Infarction
  • Stroke Volume
  • Time Factors
  • Treatment Outcome
  • Ventricular Function, Left

Cite this

@article{a0f22855a1584538aa4ffb5342317c64,
title = "Prognostic stratification of patients with ST-segment-elevation myocardial infarction (PROSPECT): A cardiac magnetic resonance study",
abstract = "Background-Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment-elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement. Methods and Results-Two hundred nine consecutive patients with ST-segment-elevation myocardial infarction (age, 61.4±11.4 years; 162 men) underwent transthoracic echocardiography and CMR after succesful primary percutaneous coronary intervention. Major adverse cardiac events (MACE) were assessed at a mean follow-up of 2.5±1.2 years. MACE occurred in 24 (12{\%}) patients who at baseline showed higher GRACE risk score (P",
keywords = "Humans, Magnetic resonance, Prognosis, ST-segment-elevation myocardial infarction, gadobenate dimeglumine, gadobenic acid, adult, Article, blood vessel occlusion, cardiovascular magnetic resonance, controlled study, coronary angiography, female, heart left ventricle ejection fraction, heart left ventricle mass, human, major adverse cardiac event, major clinical study, male, middle aged, myocardial hemorrhage, myocardial salvage index, percutaneous coronary intervention, priority journal, ST segment elevation myocardial infarction, transthoracic echocardiography, aged, bleeding, chi square distribution, cine magnetic resonance imaging, comparative study, coronary artery blood flow, diagnostic imaging, echocardiography, heart left ventricle function, heart stroke volume, microcirculation, multivariate analysis, pathophysiology, predictive value, proportional hazards model, risk factor, time factor, treatment outcome, Aged, Chi-Square Distribution, Coronary Angiography, Coronary Circulation, Echocardiography, Female, Hemorrhage, Magnetic Resonance Imaging, Cine, Male, Microcirculation, Middle Aged, Multivariate Analysis, Percutaneous Coronary Intervention, Predictive Value of Tests, Proportional Hazards Models, Risk Factors, ST Elevation Myocardial Infarction, Stroke Volume, Time Factors, Treatment Outcome, Ventricular Function, Left",
author = "G. Pontone and A.I. Guaricci and D. Andreini and G. Ferro and M. Guglielmo and A. Baggiano and L. Fusini and G. Muscogiuri and V. Lorenzoni and S. Mushtaq and E. Conte and A. Annoni and A. Formenti and M.E. Mancini and P. Carit{\`a} and M. Verdecchia and S. Pica and F. Fazzari and N. Cosentino and G. Marenzi and M.G. Rabbat and P. Agostoni and A.L. Bartorelli and M. Pepi and P.G. Masci",
note = "Export Date: 2 March 2018 Correspondence Address: Pontone, G.; Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, Italy; email: gianluca.pontone@ccfm.it Chemicals/CAS: gadobenate dimeglumine, 127000-20-8; gadobenic acid, 113662-23-0 Tradenames: multihance, Bracco, ItalyDiscovery MR450, GE Healthcare, United States Manufacturers: Bracco, ItalyGE Healthcare, United States Funding text: The study was funded by the Research Department of Centro Cardiologico Monzino, IRCCS, Milan, Italy. References: Nabel, E.G., Braunwald, E., A tale of coronary artery disease and myocardial infarction (2012) N Engl J Med, 366, pp. 54-63; Niccoli, G., Scalone, G., Lerman, A., Crea, F., Coronary microvascular obstruction in acute myocardial infarction (2016) Eur Heart J, 37, pp. 1024-1033; Yellon, D.M., Hausenloy, D.J., Myocardial reperfusion injury (2007) N Engl J Med, 357, pp. 1121-1135; Eitel, I., Thiele, H., Prognostic role of CMR imaging after myocardial infarction (2014) J Am Coll Cardiol, 64, p. 2069; Damman, P., Beijk, M.A., Kuijt, W.J., Verouden, N.J., Van Geloven, N., Henriques, J.P., Baan, J., De Winter, R.J., Multiple biomarkers at admission significantly improve the prediction of mortality in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction (2011) J Am Coll Cardiol, 57, pp. 29-36; Morrow, D.A., Antman, E.M., Charlesworth, A., Cairns, R., Murphy, S.A., De Lemos, J.A., Giugliano, R.P., Braunwald, E., TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous nPA for treatment of infarcting myocardium early II trial substudy (2000) Circulation, 102, pp. 2031-2037; Wagner, A., Mahrholdt, H., Thomson, L., Hager, S., Meinhardt, G., Rehwald, W., Parker, M., Judd, R.M., Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement (2006) J Am Coll Cardiol, 47, pp. 2027-2033; Carrick, D., Haig, C., Ahmed, N., McEntegart, M., Petrie, M.C., Eteiba, H., Hood, S., Berry, C., Myocardial hemorrhage after acute reperfused ST-segment-elevation myocardial infarction: Relation to microvascular obstruction and prognostic significance (2016) Circ Cardiovasc Imaging, 9, p. e004148; Beek, A.M., K{\"u}hl, H.P., Bondarenko, O., Twisk, J.W., Hofman, M.B., Van Dockum, W.G., Visser, C.A., Van Rossum, A.C., Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction (2003) J Am Coll Cardiol, 42, pp. 895-901; Pontone, G., Guaricci, A.I., Andreini, D., Solbiati, A., Guglielmo, M., Mushtaq, S., Baggiano, A., Pepi, M., Prognostic benefit of cardiac magnetic resonance over transthoracic echocardiography for the assessment of ischemic and nonischemic dilated cardiomyopathy patients referred for the evaluation of primary prevention implantable cardioverter-defibrillator therapy (2016) Circ Cardiovasc Imaging, 9, p. e004956; Pontone, G., Andreini, D., Guaricci, A.I., Rota, C., Guglielmo, M., Mushtaq, S., Baggiano, A., Pepi, M., The STRATEGY study (stress cardiac magnetic resonance versus computed tomography coronary angiography for the management of symptomatic revascularized patients) resources and outcomes impact (2016) Circ Cardiovasc Imaging, 9, p. e005171; Huang, W., FitzGerald, G., Goldberg, R.J., Gore, J., McManus, R.H., Awad, H., Waring, M.E., McManus, D.D., Performance of the GRACE risk score 2.0 simplified algorithm for predicting 1-year death after hospitalization for an acute coronary syndrome in a contemporary multiracial cohort (2016) Am J Cardiol, 118, pp. 1105-1110; Rentrop, K.P., Cohen, M., Blanke, H., Phillips, R.A., Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects (1985) J Am Coll Cardiol, 5, pp. 587-592; Lang, R.M., Bierig, M., Devereux, R.B., Flachskampf, F.A., Foster, E., Pellikka, P.A., Picard, M.H., Stewart, W.J., Recommendations for chamber quantification: A report from the American society of echocardiography's guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology (2005) J Am Soc Echocardiogr, 18, pp. 1440-1463; Cerqueira, M.D., Weissman, N.J., Dilsizian, V., Jacobs, A.K., Kaul, S., Laskey, W.K., Pennell, D.J., Verani, M.S., Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American Heart Association (2002) Circulation, 105, pp. 539-542; Bondarenko, O., Beek, A.M., Hofman, M.B., K{\"u}hl, H.P., Twisk, J.W., Van Dockum, W.G., Visser, C.A., Van Rossum, A.C., Standardizing the definition of hyperenhancement in the quantitative assessment of infarct size and myocardial viability using delayed contrast-enhanced CMR (2005) J Cardiovasc Magn Reson, 7, pp. 481-485; M{\"a}kikallio, T.H., Barthel, P., Schneider, R., Bauer, A., Tapanainen, J.M., Tulppo, M.P., Schmidt, G., Huikuri, H.V., Prediction of sudden cardiac death after acute myocardial infarction: Role of Holter monitoring in the modern treatment era (2005) Eur Heart J, 26, pp. 762-769; Huikuri, H.V., Raatikainen, M.J., Moerch-Joergensen, R., Hartikainen, J., Virtanen, V., Boland, J., Anttonen, O., Arrhythmias, C., And Risk Stratification after Acute Myocardial Infarction Study Group. Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction (2009) Eur Heart J, 30, pp. 689-698; Wu, K.C., Zerhouni, E.A., Judd, R.M., Lugo-Olivieri, C.H., Barouch, L.A., Schulman, S.P., Blumenthal, R.S., Lima, J.A., Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction (1998) Circulation, 97, pp. 765-772; Hombach, V., Grebe, O., Merkle, N., Waldenmaier, S., H{\"o}her, M., Kochs, M., W{\"o}hrle, J., Kestler, H.A., Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging (2005) Eur Heart J, 26, pp. 549-557; De Waha, S., Eitel, I., Desch, S., Fuernau, G., Lurz, P., Stiermaier, T., Blazek, S., Thiele, H., Prognosis after ST-elevation myocardial infarction: A study on cardiac magnetic resonance imaging versus clinical routine (2014) Trials, 15, p. 249; Bulluck, H., Go, Y.Y., Crimi, G., Ludman, A.J., Rosmini, S., Abdel-Gadir, A., Bhuva, A.N., Hausenloy, D.J., Defining left ventricular remodeling following acute ST-segment elevation myocardial infarction using cardiovascular magnetic resonance (2017) J Cardiovasc Magn Reson, 19, p. 26; Herttua, K., Martikainen, P., Batty, G.D., Kivim{\"a}ki, M., Poor adherence to statin and antihypertensive therapies as risk factors for fatal stroke (2016) J Am Coll Cardiol, 67, pp. 1507-1515; Petronio, A.S., De Carlo, M., Ciabatti, N., Amoroso, G., Limbruno, U., Palagi, C., Di Bello, V., Mariani, M., Left ventricular remodeling after primary coronary angioplasty in patients treated with abciximab or intracoronary adenosine (2005) Am Heart J, 150, p. 1015; W{\"o}hrle, J., Von Scheidt, F., Schauwecker, P., Wiesneth, M., Markovic, S., Schrezenmeier, H., Hombach, V., Bernhardt, P., Impact of cell number and microvascular obstruction in patients with bone-marrow derived cell therapy: Final results from the randomized, double-blind, placebo controlled intracoronary stem cell therapy in patients with acute myocardial infarction (SCAMI) trial (2013) Clin Res Cardiol, 102, pp. 765-770; Bulluck, H., Rosmini, S., Abdel-Gadir, A., Bhuva, A.N., Treibel, T.A., Fontana, M., Gonzalez-Lopez, E., Hausenloy, D.J., Diagnostic performance of T1 and T2 mapping to detect intramyocardial hemorrhage in reperfused ST-segment elevation myocardial infarction (STEMI) patients (2017) J Magn Reson Imaging, 46, pp. 877-886; Verhaert, D., Thavendiranathan, P., Giri, S., Mihai, G., Rajagopalan, S., Simonetti, O.P., Raman, S.V., Direct T2 quantification of myocardial edema in acute ischemic injury (2011) JACC Cardiovasc Imaging, 4, pp. 269-278; Zia, M.I., Ghugre, N.R., Connelly, K.A., Strauss, B.H., Sparkes, J.D., Dick, A.J., Wright, G.A., Characterizing myocardial edema and hemorrhage using quantitative T2 and T2.mapping at multiple time intervals post ST-segment elevation myocardial infarction (2012) Circ Cardiovasc Imaging, 5, pp. 566-572; Laursen, P.N., Holmvang, L., Kelb{\ae}k, H., Vejlstrup, N., Engstr{\o}m, T., L{\o}nborg, J., Drop-out from cardiovascular magnetic resonance in a randomized controlled trial of ST-elevation myocardial infarction does not cause selection bias on endpoints (2017) Clin Res Cardiol, 106, pp. 525-532; Gaggin, H.K., Januzzi, J.L., Jr., Natriuretic peptides in heart failure and acute coronary syndrome (2014) Clin Lab Med, 34 (6), pp. 43-58; Jenkins, W.S., Roger, V.L., Jaffe, A.S., Weston, S.A., AbouEzzeddine, O.F., Jiang, R., Manemann, S.M., Enriquez-Sarano, M., Prognostic value of soluble ST2 after myocardial infarction: A community perspective (2017) Am J Med, 130, pp. 11129-111215",
year = "2017",
doi = "10.1161/CIRCIMAGING.117.006428",
language = "English",
volume = "10",
journal = "Circulation: Cardiovascular Imaging",
issn = "1941-9651",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Prognostic stratification of patients with ST-segment-elevation myocardial infarction (PROSPECT): A cardiac magnetic resonance study

AU - Pontone, G.

AU - Guaricci, A.I.

AU - Andreini, D.

AU - Ferro, G.

AU - Guglielmo, M.

AU - Baggiano, A.

AU - Fusini, L.

AU - Muscogiuri, G.

AU - Lorenzoni, V.

AU - Mushtaq, S.

AU - Conte, E.

AU - Annoni, A.

AU - Formenti, A.

AU - Mancini, M.E.

AU - Carità, P.

AU - Verdecchia, M.

AU - Pica, S.

AU - Fazzari, F.

AU - Cosentino, N.

AU - Marenzi, G.

AU - Rabbat, M.G.

AU - Agostoni, P.

AU - Bartorelli, A.L.

AU - Pepi, M.

AU - Masci, P.G.

N1 - Export Date: 2 March 2018 Correspondence Address: Pontone, G.; Centro Cardiologico Monzino, IRCCS, Via C. Parea 4, Italy; email: gianluca.pontone@ccfm.it Chemicals/CAS: gadobenate dimeglumine, 127000-20-8; gadobenic acid, 113662-23-0 Tradenames: multihance, Bracco, ItalyDiscovery MR450, GE Healthcare, United States Manufacturers: Bracco, ItalyGE Healthcare, United States Funding text: The study was funded by the Research Department of Centro Cardiologico Monzino, IRCCS, Milan, Italy. References: Nabel, E.G., Braunwald, E., A tale of coronary artery disease and myocardial infarction (2012) N Engl J Med, 366, pp. 54-63; Niccoli, G., Scalone, G., Lerman, A., Crea, F., Coronary microvascular obstruction in acute myocardial infarction (2016) Eur Heart J, 37, pp. 1024-1033; Yellon, D.M., Hausenloy, D.J., Myocardial reperfusion injury (2007) N Engl J Med, 357, pp. 1121-1135; Eitel, I., Thiele, H., Prognostic role of CMR imaging after myocardial infarction (2014) J Am Coll Cardiol, 64, p. 2069; Damman, P., Beijk, M.A., Kuijt, W.J., Verouden, N.J., Van Geloven, N., Henriques, J.P., Baan, J., De Winter, R.J., Multiple biomarkers at admission significantly improve the prediction of mortality in patients undergoing primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction (2011) J Am Coll Cardiol, 57, pp. 29-36; Morrow, D.A., Antman, E.M., Charlesworth, A., Cairns, R., Murphy, S.A., De Lemos, J.A., Giugliano, R.P., Braunwald, E., TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous nPA for treatment of infarcting myocardium early II trial substudy (2000) Circulation, 102, pp. 2031-2037; Wagner, A., Mahrholdt, H., Thomson, L., Hager, S., Meinhardt, G., Rehwald, W., Parker, M., Judd, R.M., Effects of time, dose, and inversion time for acute myocardial infarct size measurements based on magnetic resonance imaging-delayed contrast enhancement (2006) J Am Coll Cardiol, 47, pp. 2027-2033; Carrick, D., Haig, C., Ahmed, N., McEntegart, M., Petrie, M.C., Eteiba, H., Hood, S., Berry, C., Myocardial hemorrhage after acute reperfused ST-segment-elevation myocardial infarction: Relation to microvascular obstruction and prognostic significance (2016) Circ Cardiovasc Imaging, 9, p. e004148; Beek, A.M., Kühl, H.P., Bondarenko, O., Twisk, J.W., Hofman, M.B., Van Dockum, W.G., Visser, C.A., Van Rossum, A.C., Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction (2003) J Am Coll Cardiol, 42, pp. 895-901; Pontone, G., Guaricci, A.I., Andreini, D., Solbiati, A., Guglielmo, M., Mushtaq, S., Baggiano, A., Pepi, M., Prognostic benefit of cardiac magnetic resonance over transthoracic echocardiography for the assessment of ischemic and nonischemic dilated cardiomyopathy patients referred for the evaluation of primary prevention implantable cardioverter-defibrillator therapy (2016) Circ Cardiovasc Imaging, 9, p. e004956; Pontone, G., Andreini, D., Guaricci, A.I., Rota, C., Guglielmo, M., Mushtaq, S., Baggiano, A., Pepi, M., The STRATEGY study (stress cardiac magnetic resonance versus computed tomography coronary angiography for the management of symptomatic revascularized patients) resources and outcomes impact (2016) Circ Cardiovasc Imaging, 9, p. e005171; Huang, W., FitzGerald, G., Goldberg, R.J., Gore, J., McManus, R.H., Awad, H., Waring, M.E., McManus, D.D., Performance of the GRACE risk score 2.0 simplified algorithm for predicting 1-year death after hospitalization for an acute coronary syndrome in a contemporary multiracial cohort (2016) Am J Cardiol, 118, pp. 1105-1110; Rentrop, K.P., Cohen, M., Blanke, H., Phillips, R.A., Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects (1985) J Am Coll Cardiol, 5, pp. 587-592; Lang, R.M., Bierig, M., Devereux, R.B., Flachskampf, F.A., Foster, E., Pellikka, P.A., Picard, M.H., Stewart, W.J., Recommendations for chamber quantification: A report from the American society of echocardiography's guidelines and standards committee and the chamber quantification writing group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology (2005) J Am Soc Echocardiogr, 18, pp. 1440-1463; Cerqueira, M.D., Weissman, N.J., Dilsizian, V., Jacobs, A.K., Kaul, S., Laskey, W.K., Pennell, D.J., Verani, M.S., Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the cardiac imaging committee of the council on clinical cardiology of the American Heart Association (2002) Circulation, 105, pp. 539-542; Bondarenko, O., Beek, A.M., Hofman, M.B., Kühl, H.P., Twisk, J.W., Van Dockum, W.G., Visser, C.A., Van Rossum, A.C., Standardizing the definition of hyperenhancement in the quantitative assessment of infarct size and myocardial viability using delayed contrast-enhanced CMR (2005) J Cardiovasc Magn Reson, 7, pp. 481-485; Mäkikallio, T.H., Barthel, P., Schneider, R., Bauer, A., Tapanainen, J.M., Tulppo, M.P., Schmidt, G., Huikuri, H.V., Prediction of sudden cardiac death after acute myocardial infarction: Role of Holter monitoring in the modern treatment era (2005) Eur Heart J, 26, pp. 762-769; Huikuri, H.V., Raatikainen, M.J., Moerch-Joergensen, R., Hartikainen, J., Virtanen, V., Boland, J., Anttonen, O., Arrhythmias, C., And Risk Stratification after Acute Myocardial Infarction Study Group. Prediction of fatal or near-fatal cardiac arrhythmia events in patients with depressed left ventricular function after an acute myocardial infarction (2009) Eur Heart J, 30, pp. 689-698; Wu, K.C., Zerhouni, E.A., Judd, R.M., Lugo-Olivieri, C.H., Barouch, L.A., Schulman, S.P., Blumenthal, R.S., Lima, J.A., Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction (1998) Circulation, 97, pp. 765-772; Hombach, V., Grebe, O., Merkle, N., Waldenmaier, S., Höher, M., Kochs, M., Wöhrle, J., Kestler, H.A., Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging (2005) Eur Heart J, 26, pp. 549-557; De Waha, S., Eitel, I., Desch, S., Fuernau, G., Lurz, P., Stiermaier, T., Blazek, S., Thiele, H., Prognosis after ST-elevation myocardial infarction: A study on cardiac magnetic resonance imaging versus clinical routine (2014) Trials, 15, p. 249; Bulluck, H., Go, Y.Y., Crimi, G., Ludman, A.J., Rosmini, S., Abdel-Gadir, A., Bhuva, A.N., Hausenloy, D.J., Defining left ventricular remodeling following acute ST-segment elevation myocardial infarction using cardiovascular magnetic resonance (2017) J Cardiovasc Magn Reson, 19, p. 26; Herttua, K., Martikainen, P., Batty, G.D., Kivimäki, M., Poor adherence to statin and antihypertensive therapies as risk factors for fatal stroke (2016) J Am Coll Cardiol, 67, pp. 1507-1515; Petronio, A.S., De Carlo, M., Ciabatti, N., Amoroso, G., Limbruno, U., Palagi, C., Di Bello, V., Mariani, M., Left ventricular remodeling after primary coronary angioplasty in patients treated with abciximab or intracoronary adenosine (2005) Am Heart J, 150, p. 1015; Wöhrle, J., Von Scheidt, F., Schauwecker, P., Wiesneth, M., Markovic, S., Schrezenmeier, H., Hombach, V., Bernhardt, P., Impact of cell number and microvascular obstruction in patients with bone-marrow derived cell therapy: Final results from the randomized, double-blind, placebo controlled intracoronary stem cell therapy in patients with acute myocardial infarction (SCAMI) trial (2013) Clin Res Cardiol, 102, pp. 765-770; Bulluck, H., Rosmini, S., Abdel-Gadir, A., Bhuva, A.N., Treibel, T.A., Fontana, M., Gonzalez-Lopez, E., Hausenloy, D.J., Diagnostic performance of T1 and T2 mapping to detect intramyocardial hemorrhage in reperfused ST-segment elevation myocardial infarction (STEMI) patients (2017) J Magn Reson Imaging, 46, pp. 877-886; Verhaert, D., Thavendiranathan, P., Giri, S., Mihai, G., Rajagopalan, S., Simonetti, O.P., Raman, S.V., Direct T2 quantification of myocardial edema in acute ischemic injury (2011) JACC Cardiovasc Imaging, 4, pp. 269-278; Zia, M.I., Ghugre, N.R., Connelly, K.A., Strauss, B.H., Sparkes, J.D., Dick, A.J., Wright, G.A., Characterizing myocardial edema and hemorrhage using quantitative T2 and T2.mapping at multiple time intervals post ST-segment elevation myocardial infarction (2012) Circ Cardiovasc Imaging, 5, pp. 566-572; Laursen, P.N., Holmvang, L., Kelbæk, H., Vejlstrup, N., Engstrøm, T., Lønborg, J., Drop-out from cardiovascular magnetic resonance in a randomized controlled trial of ST-elevation myocardial infarction does not cause selection bias on endpoints (2017) Clin Res Cardiol, 106, pp. 525-532; Gaggin, H.K., Januzzi, J.L., Jr., Natriuretic peptides in heart failure and acute coronary syndrome (2014) Clin Lab Med, 34 (6), pp. 43-58; Jenkins, W.S., Roger, V.L., Jaffe, A.S., Weston, S.A., AbouEzzeddine, O.F., Jiang, R., Manemann, S.M., Enriquez-Sarano, M., Prognostic value of soluble ST2 after myocardial infarction: A community perspective (2017) Am J Med, 130, pp. 11129-111215

PY - 2017

Y1 - 2017

N2 - Background-Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment-elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement. Methods and Results-Two hundred nine consecutive patients with ST-segment-elevation myocardial infarction (age, 61.4±11.4 years; 162 men) underwent transthoracic echocardiography and CMR after succesful primary percutaneous coronary intervention. Major adverse cardiac events (MACE) were assessed at a mean follow-up of 2.5±1.2 years. MACE occurred in 24 (12%) patients who at baseline showed higher GRACE risk score (P

AB - Background-Cardiac magnetic resonance (CMR) is a robust tool to evaluate left ventricular ejection fraction (LVEF), myocardial salvage index, microvascular obstruction, and myocardial hemorrhage in patients with ST-segment-elevation myocardial infarction. We evaluated the additional prognostic benefit of a CMR score over standard prognostic stratification with global registry of acute coronary events (GRACE) score and transthoracic echocardiography LVEF measurement. Methods and Results-Two hundred nine consecutive patients with ST-segment-elevation myocardial infarction (age, 61.4±11.4 years; 162 men) underwent transthoracic echocardiography and CMR after succesful primary percutaneous coronary intervention. Major adverse cardiac events (MACE) were assessed at a mean follow-up of 2.5±1.2 years. MACE occurred in 24 (12%) patients who at baseline showed higher GRACE risk score (P

KW - Humans

KW - Magnetic resonance

KW - Prognosis

KW - ST-segment-elevation myocardial infarction

KW - gadobenate dimeglumine

KW - gadobenic acid

KW - adult

KW - Article

KW - blood vessel occlusion

KW - cardiovascular magnetic resonance

KW - controlled study

KW - coronary angiography

KW - female

KW - heart left ventricle ejection fraction

KW - heart left ventricle mass

KW - human

KW - major adverse cardiac event

KW - major clinical study

KW - male

KW - middle aged

KW - myocardial hemorrhage

KW - myocardial salvage index

KW - percutaneous coronary intervention

KW - priority journal

KW - ST segment elevation myocardial infarction

KW - transthoracic echocardiography

KW - aged

KW - bleeding

KW - chi square distribution

KW - cine magnetic resonance imaging

KW - comparative study

KW - coronary artery blood flow

KW - diagnostic imaging

KW - echocardiography

KW - heart left ventricle function

KW - heart stroke volume

KW - microcirculation

KW - multivariate analysis

KW - pathophysiology

KW - predictive value

KW - proportional hazards model

KW - risk factor

KW - time factor

KW - treatment outcome

KW - Aged

KW - Chi-Square Distribution

KW - Coronary Angiography

KW - Coronary Circulation

KW - Echocardiography

KW - Female

KW - Hemorrhage

KW - Magnetic Resonance Imaging, Cine

KW - Male

KW - Microcirculation

KW - Middle Aged

KW - Multivariate Analysis

KW - Percutaneous Coronary Intervention

KW - Predictive Value of Tests

KW - Proportional Hazards Models

KW - Risk Factors

KW - ST Elevation Myocardial Infarction

KW - Stroke Volume

KW - Time Factors

KW - Treatment Outcome

KW - Ventricular Function, Left

U2 - 10.1161/CIRCIMAGING.117.006428

DO - 10.1161/CIRCIMAGING.117.006428

M3 - Article

VL - 10

JO - Circulation: Cardiovascular Imaging

JF - Circulation: Cardiovascular Imaging

SN - 1941-9651

IS - 11

ER -