Valore prognostico della coronarografia-TC a 64 strati nei pazienti diabetici con cardiopatia ischemica nota o sospetta a confronto con la popolazione non diabetica

Translated title of the contribution: Prognostic value of 64-slice coronary angiography in diabetes mellitus patients with known or suspected coronary artery disease compared with a nondiabetic population

F. Cademartiri, S. Seitun, M. Romano, E. Maffei, M. Fusaro, A. Palumbo, A. Aldrovandi, G. Messalli, S. Tresoldi, R. Malagò, V. Brambilla

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose. This study aimed to determine the prognostic value of coronary angiography with multislice computed tomography (MSCT) in a population of diabetic subjects with known or suspected ischaemic heart disease compared with a nondiabetic control population. Materials and methods. Forty-nine patients with type 2 diabetes mellitus (DM) [group 1; mean age 67.7±8.8 years; 32 men; mean body mass index (BMI) 28±3.9] and 49 patients without DM (group 2, with similar demographic and clinical characteristics) were studied with MSCT coronary angiography to exclude the presence of ischaemic coronary artery disease (CAD). Each group comprised 26 patients (53%) with no history of ischaemic coronary disease and 23 patients (47%) with a history of myocardial infarction and/or myocardial revascularisation. Clinical follow-up was performed by analysing correlations between the rate of cumulative cardiac events (cardiac death, nonfatal myocardial infarction, unstable angina, and myocardial revascularisation), the severity of CAD identified on MSCT, and the presence of DM as a cardiovascular risk factor. Results. At mean follow-up of 20 months, univariate analysis of survival showed significant differences between the two groups (group 1 vs. group 2, p=0.046). Moreover, the cumulative cardiac event rate correlated significantly with the presence of significant CAD (>50% stenosis) in both groups (group 1: p=0.003; group 2: p=0.0004). Conclusions. Event-free survival is significantly lower in the diabetic population compared with the normal control population (p=0.046) and is closely correlated with the presence of significant CAD. MSCT is an effective method for stratifying such risk and, together with high diagnostic accuracy, provides additional prognostic value.

Original languageItalian
Pages (from-to)627-643
Number of pages17
JournalRadiologia Medica
Volume113
Issue number5
DOIs
Publication statusPublished - Aug 2008

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Multidetector Computed Tomography
Coronary Angiography
Coronary Artery Disease
Diabetes Mellitus
Myocardial Revascularization
Population
Myocardial Infarction
Unstable Angina
Survival Analysis
Type 2 Diabetes Mellitus
Disease-Free Survival
Myocardial Ischemia
Coronary Disease
Pathologic Constriction
Body Mass Index
Demography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Valore prognostico della coronarografia-TC a 64 strati nei pazienti diabetici con cardiopatia ischemica nota o sospetta a confronto con la popolazione non diabetica. / Cademartiri, F.; Seitun, S.; Romano, M.; Maffei, E.; Fusaro, M.; Palumbo, A.; Aldrovandi, A.; Messalli, G.; Tresoldi, S.; Malagò, R.; Brambilla, V.

In: Radiologia Medica, Vol. 113, No. 5, 08.2008, p. 627-643.

Research output: Contribution to journalArticle

Cademartiri, F, Seitun, S, Romano, M, Maffei, E, Fusaro, M, Palumbo, A, Aldrovandi, A, Messalli, G, Tresoldi, S, Malagò, R & Brambilla, V 2008, 'Valore prognostico della coronarografia-TC a 64 strati nei pazienti diabetici con cardiopatia ischemica nota o sospetta a confronto con la popolazione non diabetica', Radiologia Medica, vol. 113, no. 5, pp. 627-643. https://doi.org/10.1007/s11547-008-0268-3
Cademartiri, F. ; Seitun, S. ; Romano, M. ; Maffei, E. ; Fusaro, M. ; Palumbo, A. ; Aldrovandi, A. ; Messalli, G. ; Tresoldi, S. ; Malagò, R. ; Brambilla, V. / Valore prognostico della coronarografia-TC a 64 strati nei pazienti diabetici con cardiopatia ischemica nota o sospetta a confronto con la popolazione non diabetica. In: Radiologia Medica. 2008 ; Vol. 113, No. 5. pp. 627-643.
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title = "Valore prognostico della coronarografia-TC a 64 strati nei pazienti diabetici con cardiopatia ischemica nota o sospetta a confronto con la popolazione non diabetica",
abstract = "Purpose. This study aimed to determine the prognostic value of coronary angiography with multislice computed tomography (MSCT) in a population of diabetic subjects with known or suspected ischaemic heart disease compared with a nondiabetic control population. Materials and methods. Forty-nine patients with type 2 diabetes mellitus (DM) [group 1; mean age 67.7±8.8 years; 32 men; mean body mass index (BMI) 28±3.9] and 49 patients without DM (group 2, with similar demographic and clinical characteristics) were studied with MSCT coronary angiography to exclude the presence of ischaemic coronary artery disease (CAD). Each group comprised 26 patients (53{\%}) with no history of ischaemic coronary disease and 23 patients (47{\%}) with a history of myocardial infarction and/or myocardial revascularisation. Clinical follow-up was performed by analysing correlations between the rate of cumulative cardiac events (cardiac death, nonfatal myocardial infarction, unstable angina, and myocardial revascularisation), the severity of CAD identified on MSCT, and the presence of DM as a cardiovascular risk factor. Results. At mean follow-up of 20 months, univariate analysis of survival showed significant differences between the two groups (group 1 vs. group 2, p=0.046). Moreover, the cumulative cardiac event rate correlated significantly with the presence of significant CAD (>50{\%} stenosis) in both groups (group 1: p=0.003; group 2: p=0.0004). Conclusions. Event-free survival is significantly lower in the diabetic population compared with the normal control population (p=0.046) and is closely correlated with the presence of significant CAD. MSCT is an effective method for stratifying such risk and, together with high diagnostic accuracy, provides additional prognostic value.",
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T1 - Valore prognostico della coronarografia-TC a 64 strati nei pazienti diabetici con cardiopatia ischemica nota o sospetta a confronto con la popolazione non diabetica

AU - Cademartiri, F.

AU - Seitun, S.

AU - Romano, M.

AU - Maffei, E.

AU - Fusaro, M.

AU - Palumbo, A.

AU - Aldrovandi, A.

AU - Messalli, G.

AU - Tresoldi, S.

AU - Malagò, R.

AU - Brambilla, V.

PY - 2008/8

Y1 - 2008/8

N2 - Purpose. This study aimed to determine the prognostic value of coronary angiography with multislice computed tomography (MSCT) in a population of diabetic subjects with known or suspected ischaemic heart disease compared with a nondiabetic control population. Materials and methods. Forty-nine patients with type 2 diabetes mellitus (DM) [group 1; mean age 67.7±8.8 years; 32 men; mean body mass index (BMI) 28±3.9] and 49 patients without DM (group 2, with similar demographic and clinical characteristics) were studied with MSCT coronary angiography to exclude the presence of ischaemic coronary artery disease (CAD). Each group comprised 26 patients (53%) with no history of ischaemic coronary disease and 23 patients (47%) with a history of myocardial infarction and/or myocardial revascularisation. Clinical follow-up was performed by analysing correlations between the rate of cumulative cardiac events (cardiac death, nonfatal myocardial infarction, unstable angina, and myocardial revascularisation), the severity of CAD identified on MSCT, and the presence of DM as a cardiovascular risk factor. Results. At mean follow-up of 20 months, univariate analysis of survival showed significant differences between the two groups (group 1 vs. group 2, p=0.046). Moreover, the cumulative cardiac event rate correlated significantly with the presence of significant CAD (>50% stenosis) in both groups (group 1: p=0.003; group 2: p=0.0004). Conclusions. Event-free survival is significantly lower in the diabetic population compared with the normal control population (p=0.046) and is closely correlated with the presence of significant CAD. MSCT is an effective method for stratifying such risk and, together with high diagnostic accuracy, provides additional prognostic value.

AB - Purpose. This study aimed to determine the prognostic value of coronary angiography with multislice computed tomography (MSCT) in a population of diabetic subjects with known or suspected ischaemic heart disease compared with a nondiabetic control population. Materials and methods. Forty-nine patients with type 2 diabetes mellitus (DM) [group 1; mean age 67.7±8.8 years; 32 men; mean body mass index (BMI) 28±3.9] and 49 patients without DM (group 2, with similar demographic and clinical characteristics) were studied with MSCT coronary angiography to exclude the presence of ischaemic coronary artery disease (CAD). Each group comprised 26 patients (53%) with no history of ischaemic coronary disease and 23 patients (47%) with a history of myocardial infarction and/or myocardial revascularisation. Clinical follow-up was performed by analysing correlations between the rate of cumulative cardiac events (cardiac death, nonfatal myocardial infarction, unstable angina, and myocardial revascularisation), the severity of CAD identified on MSCT, and the presence of DM as a cardiovascular risk factor. Results. At mean follow-up of 20 months, univariate analysis of survival showed significant differences between the two groups (group 1 vs. group 2, p=0.046). Moreover, the cumulative cardiac event rate correlated significantly with the presence of significant CAD (>50% stenosis) in both groups (group 1: p=0.003; group 2: p=0.0004). Conclusions. Event-free survival is significantly lower in the diabetic population compared with the normal control population (p=0.046) and is closely correlated with the presence of significant CAD. MSCT is an effective method for stratifying such risk and, together with high diagnostic accuracy, provides additional prognostic value.

KW - Diabetes mellitus

KW - Multislice CT

KW - Non invasive coronary angiography

KW - Prognostic value

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