Prognostic value of a history of hypertension in 11483 patients with acute myocardial infarction treated with thrombolysis

Claudio Fresco, Fausto Avanzini, Stefano Bosi, Maria Grazia Franzosi, Aldo P. Maggioni, Luigi Santoro, Giancarlo Bellanti

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the prognostic value of a history of hypertension in patients with acute myocardial infarction (AMI) treated with thrombolysis. Design: Retrospective adjusted analysis of outcome data of patients with AMI randomly allocated to treatment in a controlled study of alteplase versus streptokinase and heparin versus no heparin. Setting: A highly representative sample (about 90%) of Italian Coronary Care Units. Patients: Patients with (n=3306) and without (n=7406) a history of treated hypertension. Main outcome measures: Morbidity and mortality during hospital stay and the next 6 months. Results: Patients with a history of hypertension had a significantly higher mortality, both in hospital and during the next 6 months. The difference persisted also after a multivariate analysis including all major prognostic factors for in-hospital and 6-month mortality, respectively. Left ventricular failure and recurrent ischaemic events (angina and re-infarction) were also significantly more frequent in hypertensives both during their hospital stay and during follow-up study. Conclusions: A history of hypertension is a negative independent prognostic factor after acute myocardial infarction treated with thrombolysis.

Original languageEnglish
Pages (from-to)743-750
Number of pages8
JournalJournal of Hypertension
Volume14
Issue number6
Publication statusPublished - 1996

Keywords

  • Acute myocardial infarction
  • Arterial hypertension
  • Prognostic factor

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine

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