Prognostic value of a scorable neurological examination from 3 to 12 months post-term age in very preterm infants: A longitudinal study

Domenico M M Romeo, Matteo Cioni, Mariacristina Scoto, Alessandra Pizzardi, Mario G. Romeo, Andrea Guzzetta

Research output: Contribution to journalArticlepeer-review

Abstract

Aims and study design: The Hammersmith Infant Neurological Examination proved effective in predicting locomotor function in very preterm infants after 9 months of age. We performed the examination in a cohort of 103 very preterm infants (gestational age below 32 weeks) as early as 3 months' post-term age, and longitudinally at 6, 9 and 12 months. Our aim was to establish the frequency distribution of the optimality scores at each age period, to explore the predictive value of the examination from 3 months onwards as to developmental outcome and locomotor function at 2 years, and to explore its longitudinal consistency. Results: The results showed that this standardized neurological examination can be performed in preterm infants as early as 3 months' post-term age to predict motor outcome at 2 years, and that its high predictive value is consistent across the first year of life due to an effective combination of different items for each age period. Conclusions: We confirm the high predictive value of this neurological examination in very preterm infants after 9 months and extend it to the assessments performed as early as 3 months post-term. This is of great relevance as in very preterm infants early prediction of motor function is essential for a prompt planning of therapeutic interventions.

Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalEarly Human Development
Volume85
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Hammersmith Infant Neurological Examination
  • Motor outcome
  • Prediction
  • Premature

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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