Prognostic value of bone marrow plasma cell infiltration in stage I multiple myeloma

M. Cavo, M. Baccarani, M. Gobbi, A. Lipizer, S. Tura

Research output: Contribution to journalArticle

Abstract

We analyzed for prognosis and response to chemotherapy a series of 48 consecutive stage I myeloma patients who were treated with melphalan and prednisone soon after diagnosis. It was found that the extent of bone marrow plasma cell infiltration had prognostic value, the survival of the patients with more than 50% plasma cells being significantly shorter (P <0.005) than that of the patients with less than 50% plasma cells. In the latter group, the observed number of deaths was so small (two cases) as to preclude any further analysis. In contrast, in the former group, a significant relationship between the response to chemotherapy and patients' survival (P <0.001) was demonstrated. We conclude that a prospective randomized trial of treatment versus no treatment is warranted in stage I patients who have a high risk of death (i.e. with a high bone marrow plasma cell infiltration) in order to establish whether chemotherapy prolongs the length of survival.

Original languageEnglish
Pages (from-to)683-690
Number of pages8
JournalBritish Journal of Haematology
Volume55
Issue number4
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Hematology

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    Cavo, M., Baccarani, M., Gobbi, M., Lipizer, A., & Tura, S. (1983). Prognostic value of bone marrow plasma cell infiltration in stage I multiple myeloma. British Journal of Haematology, 55(4), 683-690.