Prognostic Value of Bone Marrow Tracer Uptake Pattern in Baseline PET Scans in Hodgkin Lymphoma: Results from an International Collaborative Study

Colette Zwarthoed, Tarec Cristoffer El-Galaly, Maria Canepari, Matthieu John Ouvrier, Julien Viotti, Marc Ettaiche, Simonetta Viviani, Luigi Rigacci, Livio Trentin, Chiara Rusconi, Stefano Luminari, Maria Cantonetti, Silvia Bolis, Anna Borra, Jacques Darcourt, Flavia Salvi, Edyta Subocz, Joanna Tajer, Waldemar Kulikowski, Bogdan MalkowskiJan Maciej Zaucha, Andrea Gallamini

Research output: Contribution to journalArticle

Abstract

PET/CT-ascertained bone marrow involvement (BMI) constitutes the single most important reason for upstaging by PET/CT in Hodgkin lymphoma (HL). However, BMI assessment in PET/CT can be challenging. This study analyzed the clinicopathologic correlations and prognostic meaning of different patterns of bone marrow (BM) 18F-FDG uptake in HL. Methods: One hundred eighty newly diagnosed early unfavorable and advanced-stage HL patients, all scanned at baseline and after 2 adriamycin-bleomycin-vinblastine-dacarbazine (ABVD) courses with 18F-FDG PET, enrolled in 2 international studies aimed at assessing the role of interim PET scanning in HL, were retrospectively included. Patients were treated with ABVD × 4-6 cycles and involved-field radiation when needed, and no treatment adaptation on interim PET scanning was allowed. Two masked reviewers independently reported the scans. Results: Thirty-eight patients (21.1%) had focal lesions (fPET+), 10 of them with a single (unifocal) and 28 with multiple (multifocal) BM lesions. Fifty-three patients (29.4%) had pure strong (>liver) diffuse uptake (dPET+) and 89 (48.4%) showed no or faint (≤liver) BM uptake (nPET+). BM biopsy was positive in 6 of 38 patients (15.7%) for fPET+, in 1 of 53 (1.9%) for dPET+, and in 5 of 89 (5.6%) for nPET+ dPET+ was correlated with younger age, higher frequency of bulky disease, lower hemoglobin levels, higher leukocyte counts, and similar diffuse uptake in the spleen. Patients with pure dPET+ had a 3-y progression-free survival identical to patients without any 18F-FDG uptake (82.9% and 82.2%, respectively, P = 0.918). However, patients with fPET+ (either unifocal or multifocal) had a 3-y progression-free survival significantly inferior to patients with dPET+ and nPET+ (66.7% and 82.5%, respectively, P = 0.03). The κ values for interobserver agreement were 0.84 for focal uptake and 0.78 for diffuse uptake. Conclusion: We confirmed that 18F-FDG PET scanning is a reliable tool for BMI assessment in HL, and BM biopsy is no longer needed for routine staging. Moreover, the interobserver agreement for BMI in this study proved excellent and only focal 18F-FDG BM uptake should be considered as a harbinger of HL.

Original languageEnglish
Pages (from-to)1249-1254
Number of pages6
JournalJournal of Nuclear Medicine
Volume58
Issue number8
DOIs
Publication statusPublished - Aug 2017

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Hodgkin Disease
Positron-Emission Tomography
Bone Marrow
Fluorodeoxyglucose F18
Dacarbazine
Vinblastine
Bleomycin
Doxorubicin
Disease-Free Survival
Biopsy
Liver
Leukocyte Count
Hemoglobins
Spleen
Radiation

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Biological Transport
  • Bone Marrow
  • Female
  • Fluorodeoxyglucose F18
  • Hodgkin Disease
  • Humans
  • Internationality
  • Male
  • Middle Aged
  • Positron-Emission Tomography
  • Prognosis
  • Radioactive Tracers
  • Retrospective Studies
  • Young Adult
  • Journal Article

Cite this

Prognostic Value of Bone Marrow Tracer Uptake Pattern in Baseline PET Scans in Hodgkin Lymphoma : Results from an International Collaborative Study. / Zwarthoed, Colette; El-Galaly, Tarec Cristoffer; Canepari, Maria; Ouvrier, Matthieu John; Viotti, Julien; Ettaiche, Marc; Viviani, Simonetta; Rigacci, Luigi; Trentin, Livio; Rusconi, Chiara; Luminari, Stefano; Cantonetti, Maria; Bolis, Silvia; Borra, Anna; Darcourt, Jacques; Salvi, Flavia; Subocz, Edyta; Tajer, Joanna; Kulikowski, Waldemar; Malkowski, Bogdan; Zaucha, Jan Maciej; Gallamini, Andrea.

In: Journal of Nuclear Medicine, Vol. 58, No. 8, 08.2017, p. 1249-1254.

Research output: Contribution to journalArticle

Zwarthoed, C, El-Galaly, TC, Canepari, M, Ouvrier, MJ, Viotti, J, Ettaiche, M, Viviani, S, Rigacci, L, Trentin, L, Rusconi, C, Luminari, S, Cantonetti, M, Bolis, S, Borra, A, Darcourt, J, Salvi, F, Subocz, E, Tajer, J, Kulikowski, W, Malkowski, B, Zaucha, JM & Gallamini, A 2017, 'Prognostic Value of Bone Marrow Tracer Uptake Pattern in Baseline PET Scans in Hodgkin Lymphoma: Results from an International Collaborative Study', Journal of Nuclear Medicine, vol. 58, no. 8, pp. 1249-1254. https://doi.org/10.2967/jnumed.116.184218
Zwarthoed, Colette ; El-Galaly, Tarec Cristoffer ; Canepari, Maria ; Ouvrier, Matthieu John ; Viotti, Julien ; Ettaiche, Marc ; Viviani, Simonetta ; Rigacci, Luigi ; Trentin, Livio ; Rusconi, Chiara ; Luminari, Stefano ; Cantonetti, Maria ; Bolis, Silvia ; Borra, Anna ; Darcourt, Jacques ; Salvi, Flavia ; Subocz, Edyta ; Tajer, Joanna ; Kulikowski, Waldemar ; Malkowski, Bogdan ; Zaucha, Jan Maciej ; Gallamini, Andrea. / Prognostic Value of Bone Marrow Tracer Uptake Pattern in Baseline PET Scans in Hodgkin Lymphoma : Results from an International Collaborative Study. In: Journal of Nuclear Medicine. 2017 ; Vol. 58, No. 8. pp. 1249-1254.
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title = "Prognostic Value of Bone Marrow Tracer Uptake Pattern in Baseline PET Scans in Hodgkin Lymphoma: Results from an International Collaborative Study",
abstract = "PET/CT-ascertained bone marrow involvement (BMI) constitutes the single most important reason for upstaging by PET/CT in Hodgkin lymphoma (HL). However, BMI assessment in PET/CT can be challenging. This study analyzed the clinicopathologic correlations and prognostic meaning of different patterns of bone marrow (BM) 18F-FDG uptake in HL. Methods: One hundred eighty newly diagnosed early unfavorable and advanced-stage HL patients, all scanned at baseline and after 2 adriamycin-bleomycin-vinblastine-dacarbazine (ABVD) courses with 18F-FDG PET, enrolled in 2 international studies aimed at assessing the role of interim PET scanning in HL, were retrospectively included. Patients were treated with ABVD × 4-6 cycles and involved-field radiation when needed, and no treatment adaptation on interim PET scanning was allowed. Two masked reviewers independently reported the scans. Results: Thirty-eight patients (21.1{\%}) had focal lesions (fPET+), 10 of them with a single (unifocal) and 28 with multiple (multifocal) BM lesions. Fifty-three patients (29.4{\%}) had pure strong (>liver) diffuse uptake (dPET+) and 89 (48.4{\%}) showed no or faint (≤liver) BM uptake (nPET+). BM biopsy was positive in 6 of 38 patients (15.7{\%}) for fPET+, in 1 of 53 (1.9{\%}) for dPET+, and in 5 of 89 (5.6{\%}) for nPET+ dPET+ was correlated with younger age, higher frequency of bulky disease, lower hemoglobin levels, higher leukocyte counts, and similar diffuse uptake in the spleen. Patients with pure dPET+ had a 3-y progression-free survival identical to patients without any 18F-FDG uptake (82.9{\%} and 82.2{\%}, respectively, P = 0.918). However, patients with fPET+ (either unifocal or multifocal) had a 3-y progression-free survival significantly inferior to patients with dPET+ and nPET+ (66.7{\%} and 82.5{\%}, respectively, P = 0.03). The κ values for interobserver agreement were 0.84 for focal uptake and 0.78 for diffuse uptake. Conclusion: We confirmed that 18F-FDG PET scanning is a reliable tool for BMI assessment in HL, and BM biopsy is no longer needed for routine staging. Moreover, the interobserver agreement for BMI in this study proved excellent and only focal 18F-FDG BM uptake should be considered as a harbinger of HL.",
keywords = "Adult, Aged, Aged, 80 and over, Biological Transport, Bone Marrow, Female, Fluorodeoxyglucose F18, Hodgkin Disease, Humans, Internationality, Male, Middle Aged, Positron-Emission Tomography, Prognosis, Radioactive Tracers, Retrospective Studies, Young Adult, Journal Article",
author = "Colette Zwarthoed and El-Galaly, {Tarec Cristoffer} and Maria Canepari and Ouvrier, {Matthieu John} and Julien Viotti and Marc Ettaiche and Simonetta Viviani and Luigi Rigacci and Livio Trentin and Chiara Rusconi and Stefano Luminari and Maria Cantonetti and Silvia Bolis and Anna Borra and Jacques Darcourt and Flavia Salvi and Edyta Subocz and Joanna Tajer and Waldemar Kulikowski and Bogdan Malkowski and Zaucha, {Jan Maciej} and Andrea Gallamini",
note = "{\circledC} 2017 by the Society of Nuclear Medicine and Molecular Imaging.",
year = "2017",
month = "8",
doi = "10.2967/jnumed.116.184218",
language = "English",
volume = "58",
pages = "1249--1254",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
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}

TY - JOUR

T1 - Prognostic Value of Bone Marrow Tracer Uptake Pattern in Baseline PET Scans in Hodgkin Lymphoma

T2 - Results from an International Collaborative Study

AU - Zwarthoed, Colette

AU - El-Galaly, Tarec Cristoffer

AU - Canepari, Maria

AU - Ouvrier, Matthieu John

AU - Viotti, Julien

AU - Ettaiche, Marc

AU - Viviani, Simonetta

AU - Rigacci, Luigi

AU - Trentin, Livio

AU - Rusconi, Chiara

AU - Luminari, Stefano

AU - Cantonetti, Maria

AU - Bolis, Silvia

AU - Borra, Anna

AU - Darcourt, Jacques

AU - Salvi, Flavia

AU - Subocz, Edyta

AU - Tajer, Joanna

AU - Kulikowski, Waldemar

AU - Malkowski, Bogdan

AU - Zaucha, Jan Maciej

AU - Gallamini, Andrea

N1 - © 2017 by the Society of Nuclear Medicine and Molecular Imaging.

PY - 2017/8

Y1 - 2017/8

N2 - PET/CT-ascertained bone marrow involvement (BMI) constitutes the single most important reason for upstaging by PET/CT in Hodgkin lymphoma (HL). However, BMI assessment in PET/CT can be challenging. This study analyzed the clinicopathologic correlations and prognostic meaning of different patterns of bone marrow (BM) 18F-FDG uptake in HL. Methods: One hundred eighty newly diagnosed early unfavorable and advanced-stage HL patients, all scanned at baseline and after 2 adriamycin-bleomycin-vinblastine-dacarbazine (ABVD) courses with 18F-FDG PET, enrolled in 2 international studies aimed at assessing the role of interim PET scanning in HL, were retrospectively included. Patients were treated with ABVD × 4-6 cycles and involved-field radiation when needed, and no treatment adaptation on interim PET scanning was allowed. Two masked reviewers independently reported the scans. Results: Thirty-eight patients (21.1%) had focal lesions (fPET+), 10 of them with a single (unifocal) and 28 with multiple (multifocal) BM lesions. Fifty-three patients (29.4%) had pure strong (>liver) diffuse uptake (dPET+) and 89 (48.4%) showed no or faint (≤liver) BM uptake (nPET+). BM biopsy was positive in 6 of 38 patients (15.7%) for fPET+, in 1 of 53 (1.9%) for dPET+, and in 5 of 89 (5.6%) for nPET+ dPET+ was correlated with younger age, higher frequency of bulky disease, lower hemoglobin levels, higher leukocyte counts, and similar diffuse uptake in the spleen. Patients with pure dPET+ had a 3-y progression-free survival identical to patients without any 18F-FDG uptake (82.9% and 82.2%, respectively, P = 0.918). However, patients with fPET+ (either unifocal or multifocal) had a 3-y progression-free survival significantly inferior to patients with dPET+ and nPET+ (66.7% and 82.5%, respectively, P = 0.03). The κ values for interobserver agreement were 0.84 for focal uptake and 0.78 for diffuse uptake. Conclusion: We confirmed that 18F-FDG PET scanning is a reliable tool for BMI assessment in HL, and BM biopsy is no longer needed for routine staging. Moreover, the interobserver agreement for BMI in this study proved excellent and only focal 18F-FDG BM uptake should be considered as a harbinger of HL.

AB - PET/CT-ascertained bone marrow involvement (BMI) constitutes the single most important reason for upstaging by PET/CT in Hodgkin lymphoma (HL). However, BMI assessment in PET/CT can be challenging. This study analyzed the clinicopathologic correlations and prognostic meaning of different patterns of bone marrow (BM) 18F-FDG uptake in HL. Methods: One hundred eighty newly diagnosed early unfavorable and advanced-stage HL patients, all scanned at baseline and after 2 adriamycin-bleomycin-vinblastine-dacarbazine (ABVD) courses with 18F-FDG PET, enrolled in 2 international studies aimed at assessing the role of interim PET scanning in HL, were retrospectively included. Patients were treated with ABVD × 4-6 cycles and involved-field radiation when needed, and no treatment adaptation on interim PET scanning was allowed. Two masked reviewers independently reported the scans. Results: Thirty-eight patients (21.1%) had focal lesions (fPET+), 10 of them with a single (unifocal) and 28 with multiple (multifocal) BM lesions. Fifty-three patients (29.4%) had pure strong (>liver) diffuse uptake (dPET+) and 89 (48.4%) showed no or faint (≤liver) BM uptake (nPET+). BM biopsy was positive in 6 of 38 patients (15.7%) for fPET+, in 1 of 53 (1.9%) for dPET+, and in 5 of 89 (5.6%) for nPET+ dPET+ was correlated with younger age, higher frequency of bulky disease, lower hemoglobin levels, higher leukocyte counts, and similar diffuse uptake in the spleen. Patients with pure dPET+ had a 3-y progression-free survival identical to patients without any 18F-FDG uptake (82.9% and 82.2%, respectively, P = 0.918). However, patients with fPET+ (either unifocal or multifocal) had a 3-y progression-free survival significantly inferior to patients with dPET+ and nPET+ (66.7% and 82.5%, respectively, P = 0.03). The κ values for interobserver agreement were 0.84 for focal uptake and 0.78 for diffuse uptake. Conclusion: We confirmed that 18F-FDG PET scanning is a reliable tool for BMI assessment in HL, and BM biopsy is no longer needed for routine staging. Moreover, the interobserver agreement for BMI in this study proved excellent and only focal 18F-FDG BM uptake should be considered as a harbinger of HL.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biological Transport

KW - Bone Marrow

KW - Female

KW - Fluorodeoxyglucose F18

KW - Hodgkin Disease

KW - Humans

KW - Internationality

KW - Male

KW - Middle Aged

KW - Positron-Emission Tomography

KW - Prognosis

KW - Radioactive Tracers

KW - Retrospective Studies

KW - Young Adult

KW - Journal Article

U2 - 10.2967/jnumed.116.184218

DO - 10.2967/jnumed.116.184218

M3 - Article

C2 - 28126883

VL - 58

SP - 1249

EP - 1254

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 8

ER -