Abstract
Objective: Inflammation plays a critical role in the pathogenesis of atherosclerosis. Possible association between C-reactive protein (CRP), stress-induced myocardial ischemia and clinical outcome was investigated. Design, patients and results: We correlated scintigraphic scan and CRP values of 101 consecutive out-patients who performed an exercise stress test for evaluation of chest pain (n=49) or scheduled control after myocardial infarction (n=52). CRP levels were determined before and after exercise. Twenty-three patients had reversible defects and presented CRP levels [mean (S.D.) 5.6 (3.3) mg/l] greater than subjects with fixed [mean (S.D.) 4.6 (4.5) mg/l] or no [mean (S.D.) 2.8 (2.9) mg/l] defects. Odds ratio for the association between high (3rd, tertile, >4.7 mg/l) CRP levels and reversible defects was 5.6 (95% CI 1.6 to 20; p=0.009). During a follow-up of 2.3 (0.7) years, 18 patients reached a clinical end-point consisting in one Q-wave myocardial infarction, eight non-Q-wave myocardial infarction or unstable angina and nine percutaneous coronary interventions. When the impact of different risk factors on the development of clinical endpoint was evaluated, the hazard ratio associated with high CRP levels was 11.0 (95% CI 3.0 to 41; p
| Original language | English |
|---|---|
| Pages (from-to) | 313-317 |
| Number of pages | 5 |
| Journal | International Journal of Cardiology |
| Volume | 98 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 15 2005 |
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Keywords
- Exercise-induced ischemia
- Inflammation and myocardial ischemia
- Inflammation and prognosis
- Scintigraphic scan
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Prognostic value of C-reactive protein in patients with stress induced myocardial ischemia. / Lombardi, Federico; Tundo, Fabrizio; Terranova, Paolo; Battezzati, Pier Maria; Ramella, Marina; Bestetti, Alberto; Tagliabue, Luca.
In: International Journal of Cardiology, Vol. 98, No. 2, 15.02.2005, p. 313-317.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic value of C-reactive protein in patients with stress induced myocardial ischemia
AU - Lombardi, Federico
AU - Tundo, Fabrizio
AU - Terranova, Paolo
AU - Battezzati, Pier Maria
AU - Ramella, Marina
AU - Bestetti, Alberto
AU - Tagliabue, Luca
PY - 2005/2/15
Y1 - 2005/2/15
N2 - Objective: Inflammation plays a critical role in the pathogenesis of atherosclerosis. Possible association between C-reactive protein (CRP), stress-induced myocardial ischemia and clinical outcome was investigated. Design, patients and results: We correlated scintigraphic scan and CRP values of 101 consecutive out-patients who performed an exercise stress test for evaluation of chest pain (n=49) or scheduled control after myocardial infarction (n=52). CRP levels were determined before and after exercise. Twenty-three patients had reversible defects and presented CRP levels [mean (S.D.) 5.6 (3.3) mg/l] greater than subjects with fixed [mean (S.D.) 4.6 (4.5) mg/l] or no [mean (S.D.) 2.8 (2.9) mg/l] defects. Odds ratio for the association between high (3rd, tertile, >4.7 mg/l) CRP levels and reversible defects was 5.6 (95% CI 1.6 to 20; p=0.009). During a follow-up of 2.3 (0.7) years, 18 patients reached a clinical end-point consisting in one Q-wave myocardial infarction, eight non-Q-wave myocardial infarction or unstable angina and nine percutaneous coronary interventions. When the impact of different risk factors on the development of clinical endpoint was evaluated, the hazard ratio associated with high CRP levels was 11.0 (95% CI 3.0 to 41; p
AB - Objective: Inflammation plays a critical role in the pathogenesis of atherosclerosis. Possible association between C-reactive protein (CRP), stress-induced myocardial ischemia and clinical outcome was investigated. Design, patients and results: We correlated scintigraphic scan and CRP values of 101 consecutive out-patients who performed an exercise stress test for evaluation of chest pain (n=49) or scheduled control after myocardial infarction (n=52). CRP levels were determined before and after exercise. Twenty-three patients had reversible defects and presented CRP levels [mean (S.D.) 5.6 (3.3) mg/l] greater than subjects with fixed [mean (S.D.) 4.6 (4.5) mg/l] or no [mean (S.D.) 2.8 (2.9) mg/l] defects. Odds ratio for the association between high (3rd, tertile, >4.7 mg/l) CRP levels and reversible defects was 5.6 (95% CI 1.6 to 20; p=0.009). During a follow-up of 2.3 (0.7) years, 18 patients reached a clinical end-point consisting in one Q-wave myocardial infarction, eight non-Q-wave myocardial infarction or unstable angina and nine percutaneous coronary interventions. When the impact of different risk factors on the development of clinical endpoint was evaluated, the hazard ratio associated with high CRP levels was 11.0 (95% CI 3.0 to 41; p
KW - Exercise-induced ischemia
KW - Inflammation and myocardial ischemia
KW - Inflammation and prognosis
KW - Scintigraphic scan
UR - http://www.scopus.com/inward/record.url?scp=15944371486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=15944371486&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2003.10.058
DO - 10.1016/j.ijcard.2003.10.058
M3 - Article
C2 - 15686784
AN - SCOPUS:15944371486
VL - 98
SP - 313
EP - 317
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -