Prognostic Value of Capnography During Rest and Exercise in Patients With Heart Failure

Ross Arena, Marco Guazzi, Jonathan Myers, Paul Chase, Daniel Bensimhon, Lawrence P. Cahalin, Mary Ann Peberdy, Euan Ashley, Erin West, Daniel E. Forman

Research output: Contribution to journalArticlepeer-review


New variables obtained from cardiopulmonary exercise testing (CPX) have received attention in recent years, in particular the partial pressure of end-tidal carbon dioxide (PETCO2). The purpose of this study was to therefore comprehensively assess the ability of resting and exercise PETCO2 to predict major cardiac events in a heart failure (HF) cohort referred for CPX. A total of 963 patients with systolic HF undergoing symptom-limited CPX were included in the analysis. Resting and exercise PETCO2 along with other CPX variables were determined, and patients were followed for major adverse events. With regard to resting measures, multivariate analysis revealed that left ventricular ejection fraction was the most robust prognostic marker (PETCO2 added significant predictive value and was retained in the regression (PETCO2 apex during exercise added predictive value and was retained (PETCO2 in the assessment of systolic HF patients to date, the authors substantiate prior (smaller) studies showing prognostic utility of PETCO2, both as a resting measure (an important potential screening tool) and during exercise. These data add to the rationale to incorporate PETCO2 as a routine monitoring component in HF management.

Original languageEnglish
Pages (from-to)302-307
Number of pages6
JournalCongestive Heart Failure
Issue number6
Publication statusPublished - Nov 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Emergency Medicine
  • Emergency


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