TY - JOUR
T1 - Prognostic Value of Capnography During Rest and Exercise in Patients With Heart Failure
AU - Arena, Ross
AU - Guazzi, Marco
AU - Myers, Jonathan
AU - Chase, Paul
AU - Bensimhon, Daniel
AU - Cahalin, Lawrence P.
AU - Peberdy, Mary Ann
AU - Ashley, Euan
AU - West, Erin
AU - Forman, Daniel E.
PY - 2012/11
Y1 - 2012/11
N2 - New variables obtained from cardiopulmonary exercise testing (CPX) have received attention in recent years, in particular the partial pressure of end-tidal carbon dioxide (PETCO2). The purpose of this study was to therefore comprehensively assess the ability of resting and exercise PETCO2 to predict major cardiac events in a heart failure (HF) cohort referred for CPX. A total of 963 patients with systolic HF undergoing symptom-limited CPX were included in the analysis. Resting and exercise PETCO2 along with other CPX variables were determined, and patients were followed for major adverse events. With regard to resting measures, multivariate analysis revealed that left ventricular ejection fraction was the most robust prognostic marker (PETCO2 added significant predictive value and was retained in the regression (PETCO2 apex during exercise added predictive value and was retained (PETCO2 in the assessment of systolic HF patients to date, the authors substantiate prior (smaller) studies showing prognostic utility of PETCO2, both as a resting measure (an important potential screening tool) and during exercise. These data add to the rationale to incorporate PETCO2 as a routine monitoring component in HF management.
AB - New variables obtained from cardiopulmonary exercise testing (CPX) have received attention in recent years, in particular the partial pressure of end-tidal carbon dioxide (PETCO2). The purpose of this study was to therefore comprehensively assess the ability of resting and exercise PETCO2 to predict major cardiac events in a heart failure (HF) cohort referred for CPX. A total of 963 patients with systolic HF undergoing symptom-limited CPX were included in the analysis. Resting and exercise PETCO2 along with other CPX variables were determined, and patients were followed for major adverse events. With regard to resting measures, multivariate analysis revealed that left ventricular ejection fraction was the most robust prognostic marker (PETCO2 added significant predictive value and was retained in the regression (PETCO2 apex during exercise added predictive value and was retained (PETCO2 in the assessment of systolic HF patients to date, the authors substantiate prior (smaller) studies showing prognostic utility of PETCO2, both as a resting measure (an important potential screening tool) and during exercise. These data add to the rationale to incorporate PETCO2 as a routine monitoring component in HF management.
UR - http://www.scopus.com/inward/record.url?scp=84869885153&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869885153&partnerID=8YFLogxK
U2 - 10.1111/j.1751-7133.2012.00296.x
DO - 10.1111/j.1751-7133.2012.00296.x
M3 - Article
C2 - 22537025
AN - SCOPUS:84869885153
VL - 18
SP - 302
EP - 307
JO - Prevention and Management of Congestive Heart Failure
JF - Prevention and Management of Congestive Heart Failure
SN - 1527-5299
IS - 6
ER -