Prognostic value of circulating tumor cells in primary and metastatic breast cancer

Research output: Contribution to journalArticle

Abstract

In patients with breast cancer, there is evidence correlating the presence of circulating tumor cells (CTCs) with disease-free survival, progression-free survival and overall survival. The detection of CTCs may be useful in gaining a better understanding of the mechanisms of tumor growth and in the improvement of patient management. This review analyzes the prognostic and predictive relevance of CTCs through the principal published studies, cytometric techniques and nucleic acid-based approaches to detect CTCs, phenotypic expression of specific receptors, molecular pathways and genetic signatures for potential tailored therapies.

Original languageEnglish
Pages (from-to)203-214
Number of pages12
JournalExpert Review of Anticancer Therapy
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • breast cancer
  • cell characterization
  • circulating tumor cells
  • detection method
  • prediction
  • prognosis

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Oncology

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