Prognostic value of contrast enhanced mri in acute isolated optic neuritis a short-term follow up study

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Purpose. To correlate optic nerve Magnetic Resonance Imaging (MR!) findings with visual fonction in acute isolated optic neuritis at presentation and to define its predictive value on visual outcome Methods. 18 consecutive patients (16 F, 2 M, mean age. 29+6 5 yrs, range 15-43 yrs) with clinically diagnosed optic neuritis were enrolled in the study Complete neuro-ophthalmological examination was performed at entry and follow up (median. 29 days, range: 14-90 days). Brain and optic nerve MRI (Chemical Shift Selective Saturation of fat on Spin Echo Tl-WI after Gadolinium injection) was performed at entry. Results. MRI showed abnormal brain images suggestive of MS in 13 patients (72%) and optic nerve enhancement (ONH) in 15 (83%) which has been defined as anterior in 6 (40%), posterior in 5 (33%) and diffuse in 4 (27%) Median ONH length was 12 mm (6, 15mm) Extent of ONH statistically correlated with visual acuity (r=-0 6, p=0 02), color vision (r=-0 5, p0.02), visual field defect (r=0.6, p=001) and with presence of brain lesions (p=0.03) The same parameters did not statistically correlated with ONH location. At follow up visual function improved in 88% of patients, visual field recovered incompletely in 58% Residual visual field defect statistically correlated with ONH length and presence of multiple brain lesions at entry (p=0.04, p=0.01 respectively) Conclusions These results indicate that among optic nerve MRI findings the extent of ONH correlates and, at least partially, predicts visual function in patients with isolated optic neuritis at presentation.

Original languageEnglish
JournalInvestigative Ophthalmology and Visual Science
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Ophthalmology


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