Prognostic value of CXCL12 expression in 40 low-grade oligodendrogliomas and oligoastrocytomas

Chiara Calatozzolo, Emanuela Maderna, Bianca Pollo, Maurizio Gelati, Carlo Marras, Antonio Silvani, Danilo Croci, Amerigo Boiardi, Andrea Salmaggi

Research output: Contribution to journalArticlepeer-review

Abstract

Both clinical and biological features have been reported as prognostic factors in low-grade gliomas. Among these, histotype, tumor size, enhancement, age and genetic pattern. Microvessel density (MVD) has been correlated to clinical outcome in astrocytomas, but its impact in oligodendrogliomas and mixed tumors is not sure. The pro-angiogenic chemokine stromal cell-derived factor (SDF-1/CXCL12) and its receptor CXC chemokine receptor 4 (CXCR4) have been described in low-grade gliomas, with a correlation between CXCL12 expression and shorter time to progression (TTP). The intermediate filament Nestin is expressed in proliferating vessels. Platelet-derived growth factor B (PDGF-B) and its receptor PDGFR-b are also involved in angiogenesis and malignant progression in gliomas.

Original languageEnglish
Pages (from-to)827-832
Number of pages6
JournalCancer Biology and Therapy
Volume5
Issue number7
Publication statusPublished - Jul 2006

Keywords

  • CXCL12
  • MVD
  • Nestin
  • Oligoastrocytoma
  • Oligodendroglioma
  • PDGF-B
  • PDGFR-β
  • TTP

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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