Prognostic value of depressed midwall systolic function in cardiac light-chain amyloidosis

Stefano Perlini, Francesco Salinaro, Francesco Musca, Roberta Mussinelli, Michele Boldrini, Ambra Raimondi, Paolo Milani, Andrea Foli, Francesco Cappelli, Federico Perfetto, Giovanni Palladini, Claudio Rapezzi, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Cardiac amyloidosis represents an archetypal form of restrictive heart disease, characterized by profound diastolic dysfunction. As ejection fraction is preserved until the late stage of the disease, the majority of patients do fulfill the definition of diastolic heart failure, that is, heart failure with preserved ejection fraction (HFpEF). In another clinical model of HFpEF, that is, pressure-overload hypertrophy, depressed midwall fractional shortening (mFS) has been shown to be a powerful prognostic factor. OBJECTIVE AND METHODS: To assess the potential prognostic role of mFS in cardiac light-chain amyloidosis with preserved ejection fraction, we enrolled 221 consecutive untreated patients, in whom a first diagnosis of cardiac light-chain amyloidosis was concluded between 2008 and 2010. HFpEF was present in 181 patients. Patients in whom cardiac involvement was excluded served as controls (n=121). Prognosis was assessed after a median follow-up of 561 days. RESULTS: When compared with light-chain amyloidosis patients without myocardial involvement, cardiac light-chain amyloidosis was characterized by increased wall thickness (P

Original languageEnglish
Pages (from-to)1121-1131
Number of pages11
JournalJournal of Hypertension
Issue number5
Publication statusPublished - 2014


  • amyloidosis
  • midwall fractional shortening
  • prognosis
  • systolic function

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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