Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings: A single center experience in a cohort of 92 patients

Federico Sizzano, Paola Magistroni, Franco Locatelli, Alessandro Busca, Michele Falda, Paola Affaticati, Gina Mazzola, Anna Maria Dall'Omo, Antonio Amoroso

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the prognostic value of cytotoxic T-lymphocyte precursor frequencies (CTL-p-f) for the development of graft-versus-host disease (GvHD) in a cohort of 92 recipients of a hematopoietic stem cell transplantation from HLA-matched sibling donors. CTL-p-f and clinical variables were correlated with acute GvHD and chronic GvHD in univariate and multivariate analyses. CTL-p-f resulted an independent risk factor for severe acute GvHD. Moreover, a trend towards a correlation between CTL-p-f and chronic GvHD was observed. In summary CTL-p-f may be considered as a functional assay useful for identifying patients at high risk of severe GVHD.

Original languageEnglish
Pages (from-to)397-400
Number of pages4
JournalHaematologica
Volume91
Issue number3
Publication statusPublished - Mar 2006

Keywords

  • Cytotoxic T-lymphocyte precursor frequencies
  • Graft-versus-host disease
  • Hematopoietic stem cell transplantation

ASJC Scopus subject areas

  • Hematology

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