Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings: A single center experience in a cohort of 92 patients

Federico Sizzano; Paola Magistroni; Franco Locatelli; Alessandro Busca; Michele Falda; Paola Affaticati; Gina Mazzola; Anna Maria Dall'Omo; Antonio Amoroso

Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings: A single center experience in a cohort of 92 patients

Federico Sizzano, Paola Magistroni, Franco Locatelli, Alessandro Busca, Michele Falda, Paola Affaticati, Gina Mazzola, Anna Maria Dall'Omo, Antonio Amoroso

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the prognostic value of cytotoxic T-lymphocyte precursor frequencies (CTL-p-f) for the development of graft-versus-host disease (GvHD) in a cohort of 92 recipients of a hematopoietic stem cell transplantation from HLA-matched sibling donors. CTL-p-f and clinical variables were correlated with acute GvHD and chronic GvHD in univariate and multivariate analyses. CTL-p-f resulted an independent risk factor for severe acute GvHD. Moreover, a trend towards a correlation between CTL-p-f and chronic GvHD was observed. In summary CTL-p-f may be considered as a functional assay useful for identifying patients at high risk of severe GVHD.

Original language	English
Pages (from-to)	397-400
Number of pages	4
Journal	Haematologica
Volume	91
Issue number	3
Publication status	Published - Mar 2006

Keywords

Cytotoxic T-lymphocyte precursor frequencies
Graft-versus-host disease
Hematopoietic stem cell transplantation

ASJC Scopus subject areas

Hematology

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Sizzano, F., Magistroni, P., Locatelli, F., Busca, A., Falda, M., Affaticati, P., Mazzola, G., Dall'Omo, A. M., & Amoroso, A. (2006). Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings: A single center experience in a cohort of 92 patients. Haematologica, 91(3), 397-400.

Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings : A single center experience in a cohort of 92 patients. / Sizzano, Federico; Magistroni, Paola; Locatelli, Franco; Busca, Alessandro; Falda, Michele; Affaticati, Paola; Mazzola, Gina; Dall'Omo, Anna Maria; Amoroso, Antonio.

In: Haematologica, Vol. 91, No. 3, 03.2006, p. 397-400.

Research output: Contribution to journal › Article › peer-review

Sizzano, F, Magistroni, P, Locatelli, F, Busca, A, Falda, M, Affaticati, P, Mazzola, G, Dall'Omo, AM & Amoroso, A 2006, 'Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings: A single center experience in a cohort of 92 patients', Haematologica, vol. 91, no. 3, pp. 397-400.

Sizzano, Federico ; Magistroni, Paola ; Locatelli, Franco ; Busca, Alessandro ; Falda, Michele ; Affaticati, Paola ; Mazzola, Gina ; Dall'Omo, Anna Maria ; Amoroso, Antonio. / Prognostic value of donor cytotoxic T-lymphocyte precursor frequencies for acute graft-versus-host disease in hematopoietic stem cell transplantation from HLA-matched siblings : A single center experience in a cohort of 92 patients. In: Haematologica. 2006 ; Vol. 91, No. 3. pp. 397-400.

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abstract = "We investigated the prognostic value of cytotoxic T-lymphocyte precursor frequencies (CTL-p-f) for the development of graft-versus-host disease (GvHD) in a cohort of 92 recipients of a hematopoietic stem cell transplantation from HLA-matched sibling donors. CTL-p-f and clinical variables were correlated with acute GvHD and chronic GvHD in univariate and multivariate analyses. CTL-p-f resulted an independent risk factor for severe acute GvHD. Moreover, a trend towards a correlation between CTL-p-f and chronic GvHD was observed. In summary CTL-p-f may be considered as a functional assay useful for identifying patients at high risk of severe GVHD.",

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