Abstract
We investigated the prognostic value of cytotoxic T-lymphocyte precursor frequencies (CTL-p-f) for the development of graft-versus-host disease (GvHD) in a cohort of 92 recipients of a hematopoietic stem cell transplantation from HLA-matched sibling donors. CTL-p-f and clinical variables were correlated with acute GvHD and chronic GvHD in univariate and multivariate analyses. CTL-p-f resulted an independent risk factor for severe acute GvHD. Moreover, a trend towards a correlation between CTL-p-f and chronic GvHD was observed. In summary CTL-p-f may be considered as a functional assay useful for identifying patients at high risk of severe GVHD.
Original language | English |
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Pages (from-to) | 397-400 |
Number of pages | 4 |
Journal | Haematologica |
Volume | 91 |
Issue number | 3 |
Publication status | Published - Mar 2006 |
Keywords
- Cytotoxic T-lymphocyte precursor frequencies
- Graft-versus-host disease
- Hematopoietic stem cell transplantation
ASJC Scopus subject areas
- Hematology