Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia

Stefano Molica, Angelo Vacca, Domenico Ribatti, Antonio Cuneo, Francesco Cavazzini, Domenico Levato, Gaetano Vitelli, Luigi Tucci, Aldo M. Roccaro, Franco Dammacco

Research output: Contribution to journalArticle

Abstract

Because tumor progression is angiogenesis-dependent, angiogenesis density was investigated by immunohistochemistry and computed image analysis in bone marrow (BM) biopsies of 45 newly diagnosed patients with Binet stage A B-cell chronic lymphocytic leukemia (BCLL) and correlated to upstaging and progression-free survival during a 40-month follow-up period. Their microvessel areas and counts were significantly higher than those of patients with anemia due to iron or vitamin B12 deficiencies. A cutoff value of 0.90 mm2 × 10-2 or greater of the microvessel area identified patients with earlier upstaging and shorter progression-free survival. When the cut-off was applied to the Rai subclassification, both Rai 0 and Rai I-II patients who upstaged and shortened the progression-free survival were classified correctly. Information of this type was not given by the microvessel counts. The cutoff did not correlate with other predictors representative of tumor mass or disease progression. The microvessel area correlated with the expression of angiogenic vascular endothelial growth factor (VEGF) by tumor tissue, and serum levels of VEGF were found to be of prognostic value. A causal relationship between risk of progression and BM angiogenesis in BCLL is suggested. A risk stratification inside Rai is proposed. The prognostic usefulness of BM angiogenesis in patients with BCLL is envisaged.

Original languageEnglish
Pages (from-to)3344-3351
Number of pages8
JournalBlood
Volume100
Issue number9
DOIs
Publication statusPublished - Nov 1 2002

ASJC Scopus subject areas

  • Hematology

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    Molica, S., Vacca, A., Ribatti, D., Cuneo, A., Cavazzini, F., Levato, D., Vitelli, G., Tucci, L., Roccaro, A. M., & Dammacco, F. (2002). Prognostic value of enhanced bone marrow angiogenesis in early B-cell chronic lymphocytic leukemia. Blood, 100(9), 3344-3351. https://doi.org/10.1182/blood-2002-01-0084