Valeur pronostique des polyamines érythrocytaires dans le cancer du rein. Étude chez 418 patients

Translated title of the contribution: Prognostic value of erythrocyte polyamines levels in renal cell carcinoma. Prospective study in 418 cases

P. Bigot, G. Lughezzani, K. Bensalah, N. Rioux-Leclercq, F. Guillé, B. Lobel, J. P. Moulinoux, V. Catros-Quemener, B. Cipolla, A. R. Azzouzi, P. Karakiewicz, J. J. Patard

Research output: Contribution to journalArticle

Abstract

Objectives: Polyamines: Spermine (Spm) and Spermidine (Spmd), are essential for cell proliferation and differentiation. A measurement of erythocytes polyamines (EPA) was developed in our institution. Our objective was to evaluate this marker as a new prognostic factor in renal cell carcinoma. Patients and methods: A blood sample was prospectively taken before surgery, among 418 patients who had an enlarged nephrectomy (n = 318) or a partial nephrectomy (n = 100) to quantify EPA rates by using the HPLC technique. The qualitative and quantitative variables have been compared using chi2 and Student statistical analyses. The survivals have been normalized by the Kaplan Meier and Cox methods. Results: The average age of our population was 64 years (21-88). The average decline was 41 months (1-214). The median size of tumors was 6.5 cm (1-24). The median rate of Spm and Spmd were respectively 4.7 (1-83) and 9 (2-86) nmol/8.109 erythrocytes. Spm and Spmd were linked to the T stage (p = 0.001), and the ECOG (p = 0.001 and 0,008). Spm was not linked at N and M stages but at the Fuhrman grade (p = 0.001). Spmd was linked to the N, M stages (p = 0.04). With univariate analysis, the tumor diameter, the TNM stage, the Fuhrman grade as well as Spm and Spmd (p <0.0001) were predictors of specific survival. With multivariate analysis, some prognostic factors remained independent: the TNM stage, the ECOG and Spmd, a continuous variable (p = 0.0001), pushing the rank of Fuhrman out of the model. When Spm and Spmd were dichotomized in quantitative variables, they were both independent factors. Conclusion: The EPA is a new prognostic tool, before surgery, which will be tested for its integration into prognostic normograms.

Translated title of the contributionPrognostic value of erythrocyte polyamines levels in renal cell carcinoma. Prospective study in 418 cases
Original languageFrench
Pages (from-to)272-278
Number of pages7
JournalProgres en Urologie
Volume20
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Biomarker
  • Polyamines
  • Prognosis
  • Renal cell carcinoma
  • Spermidine
  • Spermine

ASJC Scopus subject areas

  • Urology

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    Bigot, P., Lughezzani, G., Bensalah, K., Rioux-Leclercq, N., Guillé, F., Lobel, B., Moulinoux, J. P., Catros-Quemener, V., Cipolla, B., Azzouzi, A. R., Karakiewicz, P., & Patard, J. J. (2010). Valeur pronostique des polyamines érythrocytaires dans le cancer du rein. Étude chez 418 patients. Progres en Urologie, 20(4), 272-278. https://doi.org/10.1016/j.purol.2009.10.020