Prognostic value of frontal QRS-T angle in patients undergoing myocardial revascularization or cardiac valve surgery

Davide Lazzeroni, Matteo Bini, Umberto Camaiora, Paolo Castiglioni, Luca Moderato, Pietro Tito Ugolotti, Lorenzo Brambilla, Valerio Brambilla, Paolo Coruzzi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: An abnormal frontal QRS-T angle (fQRSTa) is associated with increased risk of death in primary and secondary cardiovascular prevention. The aim of this study was to evaluate the fQRSTa prognostic role in patients undergoing myocardial revascularization and/or cardiac valve surgery. Methods: We enrolled and prospectively followed for 48 ± 26 months 939 subjects with available QRS and T axis data; mean age was 68 ± 12 years, 449 patients (48%) underwent myocardial revascularization, 333 (35%) cardiac valve surgery, 94 (10%) valve plus bypass graft surgery and 63 (7%) cardiac surgery for other cardiovascular (CV) diseases. The ECG variables were collected at the end of the cardiac rehabilitation program and fQRSTa was considered normal if <60° abnormal if >120° borderline otherwise. Endpoints were overall and CV mortality. Results: The fQRSTa was normal in 333 patients (36%), borderline in 285 (30%) and abnormal in 321 (34%). Overall (p = 0.012) and cardiovascular (p = 0.007) mortality were significantly higher in patients with abnormal fQRSTa even after adjusting separately for gender, PR-, QTc- intervals, presence of right or left bundle branch block and left atrial volume index. The predictive value was confirmed in patients with stable coronary artery disease (SCAD), not in patients with acute coronary syndrome or valve disease. SCAD patients with abnormal both fQRSTa and QRS axis had higher risk of overall (hazard ratio = 2.9, p < 0.0001) and CV (hazard ratio = 4.4, p < 0.0001) mortality compared with SCAD patients with normal fQRSTa, even after multivariate adjustment for age, gender, ECG intervals, left-ventricle ejection fraction and mass index. Conclusions: In SCAD patients undergoing myocardial revascularization, abnormal fQRSTa is independent predictor of overall and CV mortality.

Original languageEnglish
Pages (from-to)967-972
Number of pages6
JournalJournal of Electrocardiology
Volume51
Issue number6
DOIs
Publication statusPublished - Nov 1 2018

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Myocardial Revascularization
Heart Valves
Thoracic Surgery
Coronary Artery Disease
Bundle-Branch Block
Mortality
Electrocardiography
Acute Coronary Syndrome
Secondary Prevention
Heart Ventricles
Cardiovascular Diseases
Transplants

Keywords

  • Cardiac surgery
  • Cardiac valve disease
  • Cardiovascular prevention
  • Ischemic heart disease
  • Prognostic role
  • QRS-T angle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prognostic value of frontal QRS-T angle in patients undergoing myocardial revascularization or cardiac valve surgery. / Lazzeroni, Davide; Bini, Matteo; Camaiora, Umberto; Castiglioni, Paolo; Moderato, Luca; Ugolotti, Pietro Tito; Brambilla, Lorenzo; Brambilla, Valerio; Coruzzi, Paolo.

In: Journal of Electrocardiology, Vol. 51, No. 6, 01.11.2018, p. 967-972.

Research output: Contribution to journalArticle

Lazzeroni, Davide ; Bini, Matteo ; Camaiora, Umberto ; Castiglioni, Paolo ; Moderato, Luca ; Ugolotti, Pietro Tito ; Brambilla, Lorenzo ; Brambilla, Valerio ; Coruzzi, Paolo. / Prognostic value of frontal QRS-T angle in patients undergoing myocardial revascularization or cardiac valve surgery. In: Journal of Electrocardiology. 2018 ; Vol. 51, No. 6. pp. 967-972.
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abstract = "Background: An abnormal frontal QRS-T angle (fQRSTa) is associated with increased risk of death in primary and secondary cardiovascular prevention. The aim of this study was to evaluate the fQRSTa prognostic role in patients undergoing myocardial revascularization and/or cardiac valve surgery. Methods: We enrolled and prospectively followed for 48 ± 26 months 939 subjects with available QRS and T axis data; mean age was 68 ± 12 years, 449 patients (48{\%}) underwent myocardial revascularization, 333 (35{\%}) cardiac valve surgery, 94 (10{\%}) valve plus bypass graft surgery and 63 (7{\%}) cardiac surgery for other cardiovascular (CV) diseases. The ECG variables were collected at the end of the cardiac rehabilitation program and fQRSTa was considered normal if <60° abnormal if >120° borderline otherwise. Endpoints were overall and CV mortality. Results: The fQRSTa was normal in 333 patients (36{\%}), borderline in 285 (30{\%}) and abnormal in 321 (34{\%}). Overall (p = 0.012) and cardiovascular (p = 0.007) mortality were significantly higher in patients with abnormal fQRSTa even after adjusting separately for gender, PR-, QTc- intervals, presence of right or left bundle branch block and left atrial volume index. The predictive value was confirmed in patients with stable coronary artery disease (SCAD), not in patients with acute coronary syndrome or valve disease. SCAD patients with abnormal both fQRSTa and QRS axis had higher risk of overall (hazard ratio = 2.9, p < 0.0001) and CV (hazard ratio = 4.4, p < 0.0001) mortality compared with SCAD patients with normal fQRSTa, even after multivariate adjustment for age, gender, ECG intervals, left-ventricle ejection fraction and mass index. Conclusions: In SCAD patients undergoing myocardial revascularization, abnormal fQRSTa is independent predictor of overall and CV mortality.",
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T1 - Prognostic value of frontal QRS-T angle in patients undergoing myocardial revascularization or cardiac valve surgery

AU - Lazzeroni, Davide

AU - Bini, Matteo

AU - Camaiora, Umberto

AU - Castiglioni, Paolo

AU - Moderato, Luca

AU - Ugolotti, Pietro Tito

AU - Brambilla, Lorenzo

AU - Brambilla, Valerio

AU - Coruzzi, Paolo

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: An abnormal frontal QRS-T angle (fQRSTa) is associated with increased risk of death in primary and secondary cardiovascular prevention. The aim of this study was to evaluate the fQRSTa prognostic role in patients undergoing myocardial revascularization and/or cardiac valve surgery. Methods: We enrolled and prospectively followed for 48 ± 26 months 939 subjects with available QRS and T axis data; mean age was 68 ± 12 years, 449 patients (48%) underwent myocardial revascularization, 333 (35%) cardiac valve surgery, 94 (10%) valve plus bypass graft surgery and 63 (7%) cardiac surgery for other cardiovascular (CV) diseases. The ECG variables were collected at the end of the cardiac rehabilitation program and fQRSTa was considered normal if <60° abnormal if >120° borderline otherwise. Endpoints were overall and CV mortality. Results: The fQRSTa was normal in 333 patients (36%), borderline in 285 (30%) and abnormal in 321 (34%). Overall (p = 0.012) and cardiovascular (p = 0.007) mortality were significantly higher in patients with abnormal fQRSTa even after adjusting separately for gender, PR-, QTc- intervals, presence of right or left bundle branch block and left atrial volume index. The predictive value was confirmed in patients with stable coronary artery disease (SCAD), not in patients with acute coronary syndrome or valve disease. SCAD patients with abnormal both fQRSTa and QRS axis had higher risk of overall (hazard ratio = 2.9, p < 0.0001) and CV (hazard ratio = 4.4, p < 0.0001) mortality compared with SCAD patients with normal fQRSTa, even after multivariate adjustment for age, gender, ECG intervals, left-ventricle ejection fraction and mass index. Conclusions: In SCAD patients undergoing myocardial revascularization, abnormal fQRSTa is independent predictor of overall and CV mortality.

AB - Background: An abnormal frontal QRS-T angle (fQRSTa) is associated with increased risk of death in primary and secondary cardiovascular prevention. The aim of this study was to evaluate the fQRSTa prognostic role in patients undergoing myocardial revascularization and/or cardiac valve surgery. Methods: We enrolled and prospectively followed for 48 ± 26 months 939 subjects with available QRS and T axis data; mean age was 68 ± 12 years, 449 patients (48%) underwent myocardial revascularization, 333 (35%) cardiac valve surgery, 94 (10%) valve plus bypass graft surgery and 63 (7%) cardiac surgery for other cardiovascular (CV) diseases. The ECG variables were collected at the end of the cardiac rehabilitation program and fQRSTa was considered normal if <60° abnormal if >120° borderline otherwise. Endpoints were overall and CV mortality. Results: The fQRSTa was normal in 333 patients (36%), borderline in 285 (30%) and abnormal in 321 (34%). Overall (p = 0.012) and cardiovascular (p = 0.007) mortality were significantly higher in patients with abnormal fQRSTa even after adjusting separately for gender, PR-, QTc- intervals, presence of right or left bundle branch block and left atrial volume index. The predictive value was confirmed in patients with stable coronary artery disease (SCAD), not in patients with acute coronary syndrome or valve disease. SCAD patients with abnormal both fQRSTa and QRS axis had higher risk of overall (hazard ratio = 2.9, p < 0.0001) and CV (hazard ratio = 4.4, p < 0.0001) mortality compared with SCAD patients with normal fQRSTa, even after multivariate adjustment for age, gender, ECG intervals, left-ventricle ejection fraction and mass index. Conclusions: In SCAD patients undergoing myocardial revascularization, abnormal fQRSTa is independent predictor of overall and CV mortality.

KW - Cardiac surgery

KW - Cardiac valve disease

KW - Cardiovascular prevention

KW - Ischemic heart disease

KW - Prognostic role

KW - QRS-T angle

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