Prognostic value of heart rate recovery in patients with heart failure

Ross Arena, Marco Guazzi, Jonathan Myers, Mary Ann Peberdy

Research output: Contribution to journalArticlepeer-review


Background: The rate in which heart rate recovers from exercise has recently been shown to be a strong predictor of mortality in patients suspected of having coronary disease, but its prognostic value in patients with heart failure (HF) has not been explored. We sought to assess the prognostic utility of heart rate recovery (HRR) in patients with HF. Methods: Eighty-seven subjects diagnosed with compensated HF underwent cardiopulmonary exercise testing (CPX). Mean age and ejection fraction were 50.0 (±13.9) years and 28.1% (±13.6%), respectively. Heart rate at 1-minute post-CPX was subtracted from maximal heart rate during the exercise test to produce a measure of HRR1 in beats per minute. Subjects were followed for a combined death/hospitalization end point for 1-year after CPX. Results: The mean peak respiratory exchange ratio, peak oxygen consumption (Vo2), minute ventilation/carbon dioxide production (VE/Vco2) slope, and HRR 1 were 1.06 (±0.11), 14.8 (±4.7) mL • kg -1 • min-1, 36.6 (±8.6), and 11.0 (±10.4) beat/min, respectively. Although all three variables were significant univariate predictors of the composite end point (P <.001), multivariate Cox regression analysis only retained the VE/Vco2 slope (χ2 = 33.5, P <.001) and HRR1 (residual χ2 = 15.0, P <.001) in the equation. The hazard ratio for subjects having both an abnormal VE/Vco2 slope (>34.4) and HRR1 (

Original languageEnglish
JournalAmerican Heart Journal
Issue number4
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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