Prognostic Value of Heart Rate Turbulence and Its Relation to Inflammation in Patients With Unstable Angina Pectoris

Gaetano A. Lanza, Gregory A. Sgueglia, Giulia Angeloni, Sergio Valsecchi, Alfonso Sestito, Antonio G. Rebuzzi, Filippo Crea, Attilio Maseri, Domenico Cianflone

Research output: Contribution to journalArticlepeer-review

Abstract

Heart rate turbulence (HRT) provided insights into cardiac autonomic function and predicted clinical outcome in patients with myocardial infarction. A relation between cardiac autonomic function and inflammation was shown in several clinical settings. To assess the prognostic impact of HRT and its relation with inflammation in patients with unstable angina pectoris (UAP), HRT parameters (turbulence onset [TO] and turbulence slope [TS]) were measured in 331 patients with UAP (age 66.4 ± 10 years; 231 men) with premature ventricular complexes on electrocardiographic Holter monitoring. Total and cardiac mortality were assessed at the 6-month follow-up. The 6th (-1.52%) and 4th deciles (4.90 ms/RR) were the best prognostic cut-off values for TO and TS, respectively. TS -1.52% were 2.94 (95% CI 1.11 to 7.81, p = 0.03) and 3.33 (95% CI 1.13 to 9.79, p = 0.029), respectively. Patients with TO 4.9 ms/RR showed very low risks of total and cardiac mortality (1.8% and 0.9%, respectively). TS

Original languageEnglish
Pages (from-to)1066-1072
Number of pages7
JournalThe American Journal of Cardiology
Volume103
Issue number8
DOIs
Publication statusPublished - Apr 15 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Prognostic Value of Heart Rate Turbulence and Its Relation to Inflammation in Patients With Unstable Angina Pectoris'. Together they form a unique fingerprint.

Cite this