TY - JOUR
T1 - Prognostic Value of Heart Rate Turbulence and Its Relation to Inflammation in Patients With Unstable Angina Pectoris
AU - Lanza, Gaetano A.
AU - Sgueglia, Gregory A.
AU - Angeloni, Giulia
AU - Valsecchi, Sergio
AU - Sestito, Alfonso
AU - Rebuzzi, Antonio G.
AU - Crea, Filippo
AU - Maseri, Attilio
AU - Cianflone, Domenico
PY - 2009/4/15
Y1 - 2009/4/15
N2 - Heart rate turbulence (HRT) provided insights into cardiac autonomic function and predicted clinical outcome in patients with myocardial infarction. A relation between cardiac autonomic function and inflammation was shown in several clinical settings. To assess the prognostic impact of HRT and its relation with inflammation in patients with unstable angina pectoris (UAP), HRT parameters (turbulence onset [TO] and turbulence slope [TS]) were measured in 331 patients with UAP (age 66.4 ± 10 years; 231 men) with premature ventricular complexes on electrocardiographic Holter monitoring. Total and cardiac mortality were assessed at the 6-month follow-up. The 6th (-1.52%) and 4th deciles (4.90 ms/RR) were the best prognostic cut-off values for TO and TS, respectively. TS -1.52% were 2.94 (95% CI 1.11 to 7.81, p = 0.03) and 3.33 (95% CI 1.13 to 9.79, p = 0.029), respectively. Patients with TO 4.9 ms/RR showed very low risks of total and cardiac mortality (1.8% and 0.9%, respectively). TS
AB - Heart rate turbulence (HRT) provided insights into cardiac autonomic function and predicted clinical outcome in patients with myocardial infarction. A relation between cardiac autonomic function and inflammation was shown in several clinical settings. To assess the prognostic impact of HRT and its relation with inflammation in patients with unstable angina pectoris (UAP), HRT parameters (turbulence onset [TO] and turbulence slope [TS]) were measured in 331 patients with UAP (age 66.4 ± 10 years; 231 men) with premature ventricular complexes on electrocardiographic Holter monitoring. Total and cardiac mortality were assessed at the 6-month follow-up. The 6th (-1.52%) and 4th deciles (4.90 ms/RR) were the best prognostic cut-off values for TO and TS, respectively. TS -1.52% were 2.94 (95% CI 1.11 to 7.81, p = 0.03) and 3.33 (95% CI 1.13 to 9.79, p = 0.029), respectively. Patients with TO 4.9 ms/RR showed very low risks of total and cardiac mortality (1.8% and 0.9%, respectively). TS
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U2 - 10.1016/j.amjcard.2009.01.006
DO - 10.1016/j.amjcard.2009.01.006
M3 - Article
C2 - 19361591
AN - SCOPUS:63749112574
VL - 103
SP - 1066
EP - 1072
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 8
ER -