Prognostic value of immunohistochemical expression of p53, bax, Bcl-2 and Bcl-xL in resected non-small-cell lung cancers

A. M. Groeger, V. Esposito, A. De Luca, R. Cassandro, G. Tonini, V. Ambrogi, F. Baldi, R. Goldfarb, T. C. Mineo, A. Baldi, E. Wolner

Research output: Contribution to journalArticle

Abstract

Aims: Some experimental evidence suggests that in lung cancer, development, progression and an increased proliferation rate can be linked to apoptosis-related factors. In this study we evaluated the possible role of p53 and Bcl-2 gene family members as prognostic factors for non-small-cell lung cancer. Methods and results: We investigated the immunohistochemical expression of p53 and Bcl-2 gene family members (bax, Bcl-2 and Bcl-xL) in 94 non-small-cell lung cancer specimens to establish the role of these genes in lung cancer pathogenesis, and to evaluate their prognostic importance. The expression of Bcl-2 was correlated with a shorter patient survival time and with the nodal status of the neoplasm. We also found frequent over-expression of bax and Bcl-xL to be of no prognostic significance. Finally, we found no correlation between frequent detection of aberrant p53 protein and expression of either Bcl-2, bax or Bcl-xL or with patient survival time. Conclusions: This study confirms a relevant role for apoptosis-regulatory proteins in the pathogenesis of lung cancer, and highlights the possible role of Bcl-2 as a prognostic factor for this tumour.

Original languageEnglish
Pages (from-to)54-63
Number of pages10
JournalHistopathology
Volume44
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Bax
  • Bcl-2
  • Non-small-cell lung cancer
  • p53
  • Prognosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Cell Biology

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    Groeger, A. M., Esposito, V., De Luca, A., Cassandro, R., Tonini, G., Ambrogi, V., Baldi, F., Goldfarb, R., Mineo, T. C., Baldi, A., & Wolner, E. (2004). Prognostic value of immunohistochemical expression of p53, bax, Bcl-2 and Bcl-xL in resected non-small-cell lung cancers. Histopathology, 44(1), 54-63. https://doi.org/10.1111/j.1365-2559.2004.01750.x