Prognostic value of infection from human papillomavirus 16 and 18 in the follow-up of patients submitted to conization for cervical intraepithelial neoplasia grade III

A. Sedati, L. Mariani, R. Giovinazzi, G. Badaracco, A. Venuti, G. Atlante

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Abstract

In an attempt to establish the role of the human papillomaviruses (HPV) 16 and 18 in the genesis of cervical precancerous lesions, 20 patients submitted to conization for cervical intraepithelial neoplasia (CIN) grade II were evaluated. All patients were followed-up with colposcopy, cytology, microcolpohysteroscopy (MCH) and dot- or Southern-blot hybridization on the cervical scrapes. Ten patients (50%) were positive for the presence of fragments of the HPV 16 and 18 viral genomes. Of these, 2 later developed CIN II with viral cytopathic effects (VCE). However, of the patients who responded negatively to the hybridization tests, none developed CIN. Although the present study includes only a small number of patients, the results obtained are in accord with some international reports which point to the significant role of HPV 16 and 18 infection in the natural history of CIN. At the present time, although a modification of therapeutic schemes in relation to the viral subtypes present in the lesions cannot be proposed, the need to strictly follow-up patients affected with 'high-risk' HPV, such as HPV 16 and 18, should be stressed.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalCervix and the Lower Female Genital Tract
Volume9
Issue number1
Publication statusPublished - 1991

Fingerprint

Conization
Human papillomavirus 18
Cervical Intraepithelial Neoplasia
Human papillomavirus 16
Infection
Viral Cytopathogenic Effect
Colposcopy
Viral Genome
Southern Blotting
Cell Biology

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

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title = "Prognostic value of infection from human papillomavirus 16 and 18 in the follow-up of patients submitted to conization for cervical intraepithelial neoplasia grade III",
abstract = "In an attempt to establish the role of the human papillomaviruses (HPV) 16 and 18 in the genesis of cervical precancerous lesions, 20 patients submitted to conization for cervical intraepithelial neoplasia (CIN) grade II were evaluated. All patients were followed-up with colposcopy, cytology, microcolpohysteroscopy (MCH) and dot- or Southern-blot hybridization on the cervical scrapes. Ten patients (50{\%}) were positive for the presence of fragments of the HPV 16 and 18 viral genomes. Of these, 2 later developed CIN II with viral cytopathic effects (VCE). However, of the patients who responded negatively to the hybridization tests, none developed CIN. Although the present study includes only a small number of patients, the results obtained are in accord with some international reports which point to the significant role of HPV 16 and 18 infection in the natural history of CIN. At the present time, although a modification of therapeutic schemes in relation to the viral subtypes present in the lesions cannot be proposed, the need to strictly follow-up patients affected with 'high-risk' HPV, such as HPV 16 and 18, should be stressed.",
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T1 - Prognostic value of infection from human papillomavirus 16 and 18 in the follow-up of patients submitted to conization for cervical intraepithelial neoplasia grade III

AU - Sedati, A.

AU - Mariani, L.

AU - Giovinazzi, R.

AU - Badaracco, G.

AU - Venuti, A.

AU - Atlante, G.

PY - 1991

Y1 - 1991

N2 - In an attempt to establish the role of the human papillomaviruses (HPV) 16 and 18 in the genesis of cervical precancerous lesions, 20 patients submitted to conization for cervical intraepithelial neoplasia (CIN) grade II were evaluated. All patients were followed-up with colposcopy, cytology, microcolpohysteroscopy (MCH) and dot- or Southern-blot hybridization on the cervical scrapes. Ten patients (50%) were positive for the presence of fragments of the HPV 16 and 18 viral genomes. Of these, 2 later developed CIN II with viral cytopathic effects (VCE). However, of the patients who responded negatively to the hybridization tests, none developed CIN. Although the present study includes only a small number of patients, the results obtained are in accord with some international reports which point to the significant role of HPV 16 and 18 infection in the natural history of CIN. At the present time, although a modification of therapeutic schemes in relation to the viral subtypes present in the lesions cannot be proposed, the need to strictly follow-up patients affected with 'high-risk' HPV, such as HPV 16 and 18, should be stressed.

AB - In an attempt to establish the role of the human papillomaviruses (HPV) 16 and 18 in the genesis of cervical precancerous lesions, 20 patients submitted to conization for cervical intraepithelial neoplasia (CIN) grade II were evaluated. All patients were followed-up with colposcopy, cytology, microcolpohysteroscopy (MCH) and dot- or Southern-blot hybridization on the cervical scrapes. Ten patients (50%) were positive for the presence of fragments of the HPV 16 and 18 viral genomes. Of these, 2 later developed CIN II with viral cytopathic effects (VCE). However, of the patients who responded negatively to the hybridization tests, none developed CIN. Although the present study includes only a small number of patients, the results obtained are in accord with some international reports which point to the significant role of HPV 16 and 18 infection in the natural history of CIN. At the present time, although a modification of therapeutic schemes in relation to the viral subtypes present in the lesions cannot be proposed, the need to strictly follow-up patients affected with 'high-risk' HPV, such as HPV 16 and 18, should be stressed.

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