Prognostic value of intratumoral microvessel density, a measure of tumor angiogenesis, in node-negative breast carcinoma - results of a multiparametric study

Pierantonio Bevilacqua, Mattia Barbareschi, Paolo Verderio, Patrizia Boracchi, Orazio Caffo, Paolo Dalla Palma, Salvatore Meli, Noel Weidner, Giampietro Gasparini

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study we update previous results on the prognostic value of intratumoral microvessel density (IMD), determined immunocytochemically using the monoclonal antibody CD-31 and a standard streptavidin-immunoperoxidase technique, published in the J Clin Oncol 12:454-466, 1994. This study was undertaken in those 211 node-negative breast cancer (NNBC) cases of that series of which we had pathological material available to determine all the prognostic indicators. The median period of follow-up has been extended to 78 and 80 months for relapse-free survival (RFS) and overall survival (OS), respectively, and new biological indicators (i.e. Ki-67 labeling and 67 kDa laminin receptor expression) were included in the analysis. The main results obtained are:i) a confirmation that IMD is not associated with the other biological markers studied, i.e. expression of p53 protein, c-erbB-2 protein, 67 kDa laminin receptor, and cell kinetics; IMD was weakly associated only with histological grade (p=0.053);ii) IMD remains a highly significant prognostic factor for RFS and OS (p

Original languageEnglish
Pages (from-to)205-217
Number of pages13
JournalBreast Cancer Research and Treatment
Volume36
Issue number2
DOIs
Publication statusPublished - Jan 1995

Keywords

  • c-erbB-2 protein
  • histologic grade
  • Ki-67
  • laminin receptor
  • multivariate analysis
  • node-negative breast cancer
  • p53
  • peritumoral lymphatic vessel invasion
  • prognosis
  • tumor angiogenesis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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