Prognostic value of low density lipoprotein receptor expression in colorectal carcinoma

Maria Gabriella Caruso, Alberto Ruben Osella, Maria Notarnicola, Pasquale Berloco, Silvana Leo, Caterina Bonfiglio, Alfredo Di Leo

Research output: Contribution to journalArticle

Abstract

Cancer cells require more cholesterol than normal cells. This requirement seems to be satisfied by a higher HMG-CoA reductase activity or a higher activity of low density lipoprotein receptor (LDLR). We investigated the prognostic value of LDLR in colorectal carcinoma (CRC) patients. The LDLR was evaluated in 90 patients with CRC by ELISA. The survival time and the relative risk of prognostic factors were analyzed by Kaplan-Meier estimates and Cox proportional hazard model. Thirty three cases were LDLR positive (+), while 57 LDLR negative (-). The survival of LDLR(-) patients was shorter than that of LDLR(+). By Cox model, the absence of LDLR and time until metastasis resulted significantly associated with the CRC-related survival. The absence of LDLR in CRC predicts a shorter survival.

Original languageEnglish
Pages (from-to)927-930
Number of pages4
JournalOncology Reports
Volume5
Issue number4
Publication statusPublished - 1998

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Keywords

  • Colorectal carcinoma
  • Low density lipoprotein receptor
  • Survival analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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