Abstract
The understanding of the molecular mechanisms that underlie all stages of tumor progression in breast cancer (BC) represents an important goal in the biomedical research of this disease, particularly for the identification of more specific targeted therapies. In this context, BC preinvasive and precursor lesions represent a major dilemma. These lesions are well characterized under the phenotypic and genotypic profile, but it is not clear if they represent obligatory passages of a multistep process determining breast cancer evolution. In fact, the numerous cytogenetic and molecular alterations identified are not always representative of the progression into invasive phenotypes.
| Original language | English |
|---|---|
| Pages (from-to) | 1181-1183 |
| Number of pages | 3 |
| Journal | Oncology Letters |
| Volume | 6 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Breast cancer precursor lesions
- Molecular alterations
- Tumor progression
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Prognostic value of molecular markers and cytogenetic alterations that characterize breast cancer precursor lesions (review). / Di Bonito, Maurizio; Cantile, Monica; De Cecio, Rossella; Liguori, Giuseppina; Botti, Gerardo.
In: Oncology Letters, Vol. 6, No. 5, 11.2013, p. 1181-1183.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic value of molecular markers and cytogenetic alterations that characterize breast cancer precursor lesions (review)
AU - Di Bonito, Maurizio
AU - Cantile, Monica
AU - De Cecio, Rossella
AU - Liguori, Giuseppina
AU - Botti, Gerardo
PY - 2013/11
Y1 - 2013/11
N2 - The understanding of the molecular mechanisms that underlie all stages of tumor progression in breast cancer (BC) represents an important goal in the biomedical research of this disease, particularly for the identification of more specific targeted therapies. In this context, BC preinvasive and precursor lesions represent a major dilemma. These lesions are well characterized under the phenotypic and genotypic profile, but it is not clear if they represent obligatory passages of a multistep process determining breast cancer evolution. In fact, the numerous cytogenetic and molecular alterations identified are not always representative of the progression into invasive phenotypes.
AB - The understanding of the molecular mechanisms that underlie all stages of tumor progression in breast cancer (BC) represents an important goal in the biomedical research of this disease, particularly for the identification of more specific targeted therapies. In this context, BC preinvasive and precursor lesions represent a major dilemma. These lesions are well characterized under the phenotypic and genotypic profile, but it is not clear if they represent obligatory passages of a multistep process determining breast cancer evolution. In fact, the numerous cytogenetic and molecular alterations identified are not always representative of the progression into invasive phenotypes.
KW - Breast cancer precursor lesions
KW - Molecular alterations
KW - Tumor progression
UR - http://www.scopus.com/inward/record.url?scp=84884493405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884493405&partnerID=8YFLogxK
U2 - 10.3892/ol.2013.1589
DO - 10.3892/ol.2013.1589
M3 - Article
VL - 6
SP - 1181
EP - 1183
JO - Oncology Letters
JF - Oncology Letters
SN - 1792-1074
IS - 5
ER -