Prognostic value of Nocturnal Cheyne-Stokes respiration in chronic heart failure

Paola A. Lanfranchi, Alberto Braghiroli, Enzo Bosimini, Giorgio Mazzuero, Roberto Colombo, Claudio F. Donner, Pantaleo Giannuzzi

Research output: Contribution to journalArticlepeer-review


Background - -Nocturnal Cheyne-Stokes respiration (CSR) occurs frequently in patients with chronic heart failure (CHF), and it may be associated with sympathetic activation. The aim of the present study was to evaluate whether CSR could affect prognosis in patients with CHF. Methods and Results - Sixty-two CHF patients with left ventricular ejection fraction ≤35%, in NYHA class II to III, underwent clinical evaluation, Doppler echocardiography, ergospirometry, phenylephrine test, Holter recording, and a sleep study to evaluate the occurrence of CSR, expressed as percentage of periodic breathing, and apnea/hypopnea index (AHI) (ie, the number of apneas and hypopneas per hour of recording). During a mean follow-up of 28±13 months, 15 patients died of cardiac causes. Nonsurvivors were in a higher NYHA functional class than survivors (P2 (P2, 10.4; P2, 5.7; P2. Conclusions - The AHI is a powerful independent predictor of poor prognosis in clinically stable patients with CHF. The presence of an AHI ≥30/h adds prognostic information compared with other clinical, echocardiographic, and autonomic data and identifies patients at very high risk for subsequent cardiac death.

Original languageEnglish
Pages (from-to)1435-1440
Number of pages6
Issue number11
Publication statusPublished - Mar 23 1999


  • Heart failure
  • Prognosis
  • Sleep

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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