Prognostic value of non invasive baroreflex sensitivity in chronic heart failure patients

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Non invasive baroreflex sensitivity (BRS) by the classical transfer function (TF) method very often cannot be assessed in chronic heart failure (CHF) patients, due to a lack of coherence between heart period and systolic pressure. On the grounds of a previous investigation, we devised a new BRS index based on the average of the TF in the whole low frequency band (WBA-BRS), which does not require coherence check. In this study we assessed the clinical relevance of this index by testing its prognostic value in a population of 149 CHF patients. During a 20 ± 12 months follow-up, 28 patients died or were urgently transplanted. Univariate relation of WBA-BRS with mortality was assessed by the Cox proportional hazards model and survival functions were estimated using the Kaplan-Meier method. We also investigated the independent effect of WBA-BRS, adjusting for NYHA class, LVEF, peak VO2, Na+. WBA-BRS showed a significant univariate association with the risk of cardiac events. When its predictive value was assessed in multivariate analysis, WBA-BRS displayed independent prognostic information (risk ratio 3.0, 95%CI: 1.1-7.9, p=0.03). These preliminary data suggest that BRS assessed by a modified version of the classical TF method is a potential prognostic marker in CHF patients.

Original languageEnglish
Title of host publicationComputers in Cardiology
Number of pages4
Publication statusPublished - 2001
EventComputer in Cardiology 2001 - Rotterdam, Netherlands
Duration: Sep 23 2001Sep 26 2001


OtherComputer in Cardiology 2001

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine


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