Prognostic value of PET-CT after fi rst-line therapy in patients with follicular lymphoma: A pooled analysis of central scan review in three multicentre studies

Judith Trotman, Stefano Luminari, Sami Boussetta, Annibale Versari, Jehan Dupuis, Christelle Tychyj, Luigi Marcheselli, Alina Berriolo-Riedinger, Antonella Franceschetto, Anne Julian, Fabien Ricard, Luca Guerra, Corinne Haioun, Irene Biasoli, Hervé Tilly, Massimo Federico, Gilles Salles, Michel Meignan

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The value of 18F-fl uorodeoxyglucose (FDG) PET-CT (PET) imaging in response assessment after fi rst-line rituximab chemotherapy for follicular lymphoma has been documented. We analysed the application of the fi ve-point Deauville scale (5PS; used to score FDG uptake on PET images) in a large cohort derived from three studies, to assess the correlation between post-induction PET status and survival in patients with follicular lymphoma. Methods: In this pooled analysis, we used data from three multicentre prospective studies of fi rst-line rituximab chemotherapy for patients with high-tumour-burden follicular lymphoma (the PRIMA study, the PET-Folliculaire study, and the Fondazione Italiana Linfomi FOLL05 study). Patients included in this analysis received at least six cycles of rituximab and chemotherapy before response assessment with conventional contrast-enhanced CT and PET low-dose CT (PET). We included only patients who had a PET scan within 3 months of the last dose of induction rituximab. Patient data, including conventional CT-based response assessment, were recorded for all patients undergoing PET review. Scans undergoing central PET review were scored independently by three reviewers according to the 5PS. The primary endpoints were progression-free survival and overall survival according to the 5PS score of post-induction PET scan (ie, positive [≥4 points] or negative [

Original languageEnglish
Pages (from-to)e17-e27
JournalThe Lancet Haematology
Volume1
Issue number1
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Hematology

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