Prognostic value of pre-surgical plasma PAI-1 (plasminogen activator inhibitor-1) levels in breast cancer

Raffaele Palmirotta, Patrizia Ferroni, Annalisa Savonarola, Francesca Martini, Filippo Ciatti, Anastasia Laudisi, Valentina Sini, Girolamo Del Monte, Fiorella Guadagni, Mario Roselli

Research output: Contribution to journalArticlepeer-review


Introduction: Plasminogen activator inhibitor (PAI-1) may have an independent prognostic value in breast cancer (BC). PAI-1 4G/5G polymorphism may have significance for antigen expression. Thus, we analyzed the possible associations between PAI-1 4G/5G polymorphism, plasma PAI-1 levels, and clinicopathological features of breast cancer (BC) patients. Patients and Methods: PAI-1 4G/5G polymorphism (both on germinal and tumor DNA) and plasma PAI-1 levels were investigated in 99 BC patients and 50 unrelated healthy women similar for age and menopausal status. Results: No association was found between allele frequencies and clinicopathological features of BC or plasma antigen levels. Plasma PAI-1 levels were higher in BC compared to controls (p = 0.002), particularly in patients with large tumors (p <0.001). 5-year follow-up was achieved in 79 patients: 30% had relapsing disease, 63% with positive compared to 37% with negative PAI-1 levels (p <0.05). 5-year relapse-free survival rate of positive PAI-1 was 46% vs., 77% of negative patients (p = 0.02). Conclusions: We may conclude that plasma PAI-1 levels in BC patients could represent a useful prognostic variable for relapse, although PAI-1 polymorphism might not represent a genetic susceptibility factor.

Original languageEnglish
Pages (from-to)403-408
Number of pages6
JournalThrombosis Research
Issue number4
Publication statusPublished - Sep 2009


  • Breast cancer
  • Plasminogen activator inhibitors
  • Relapse-free survival
  • Single nucleotide polymorphisms

ASJC Scopus subject areas

  • Hematology


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