Prognostic value of preoperative von Willebrand factor plasma levels in patients with Glioblastoma

Giovanni Marfia, Stefania Navone, Claudia Fanizzi, Silvia Tabano, Chiara Pesenti, Loubna Abdel Hadi, Andrea Franzini, Manuela Anna Caroli, Monica Miozzo, Laura Riboni, Paolo Rampini, R. Campanella

Research output: Contribution to journalArticle

Abstract

Circulating biomarker for malignant gliomas could improve both differential diagnosis and clinical management of brain tumor patients. Among all gliomas, glioblastoma (GBM) is considered the most hypervascularized tumor with activation of multiple proangiogenic signaling pathways that enhance tumor growth. To investigate whether preoperative antigen plasma level of von Willebrand Factor (VWF:Ag) might be possible marker for GBM onset, progression, and prognosis, we retrospectively examined 57 patients with histological diagnosis for GBM and 23 meningiomas (MNGs), benign intracranial expansive lesions, enrolled as controls. Blood samples were collected from all the patients before tumor resection. Plasma von Willebrand Factor (VWF):Ag levels were determined by using a latex particle-enhanced immunoturbidimetric assay. The median levels of vWF:Ag were significantly higher in GBMs than in meningiomas (MNGs) (183 vs. 133 IU/dL, P = 0.01). The cumulative 1-year survival was significantly shorter in patients with VWF:Ag levels >200 IU/dL than in those with levels <200 IU/dL and increased VWF levels were associated with a threefold higher risk of death in GBM patients. Our data suggest that VWF:Ag could be a circulating biomarker of disease malignancy, that could be considered, in association with other genetic and epigenetic factors, currently available in the GBM management. Future studies should investigate whether plasma VWF:Ag levels could also be used to monitor therapeutic effects and whether it may have a prognostic value.

Original languageEnglish
Pages (from-to)1783-1790
Number of pages8
JournalCancer Medicine
Volume5
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Angiogenesis
  • brain tumor
  • Glioblastoma
  • glioma.
  • vascular endothelial growth factor
  • von Willebrand Factor

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    Marfia, G., Navone, S., Fanizzi, C., Tabano, S., Pesenti, C., Abdel Hadi, L., Franzini, A., Caroli, M. A., Miozzo, M., Riboni, L., Rampini, P., & Campanella, R. (2016). Prognostic value of preoperative von Willebrand factor plasma levels in patients with Glioblastoma. Cancer Medicine, 5(8), 1783-1790. https://doi.org/10.1002/cam4.747