Prognostic Value of Programmed Electrical Stimulation in Brugada Syndrome

Juan Sieira, Giulio Conte, Giuseppe Ciconte, Carlo De Asmundis, Gian Battista Chierchia, Giannis Baltogiannis, Giacomo Di Giovanni, Yukio Saitoh, Ghazala Irfan, Ruben Casado-Arroyo, Justo Juliá, Mark La Meir, Francis Wellens, Kristel Wauters, Sophie Van Malderen, Gudrun Pappaert, Pedro Brugada

Research output: Contribution to journalArticlepeer-review


Background - The prognostic value of electrophysiological investigations in individuals with Brugada syndrome remains controversial. Different groups have published contradictory data. Long-term follow-up is needed to clarify this issue. Methods and Results - Patients presenting with spontaneous or drug-induced Brugada type I ECG and in whom programmed electric stimulation was performed at our institution were considered eligible for this study. A total of 403 consecutive patients (235 males, 58.2%; mean age, 43.2±16.2 years) were included. Ventricular arrhythmias during programmed electric stimulation were induced in 73 (18.1%) patients. After a mean follow-up time of 74.3±57.3 months (median 57.3), 25 arrhythmic events occurred (16 in the inducible group and 9 in the noninducible). Ventricular arrhythmias inducibility presented a hazard ratio for events of 8.3 (95% confidence interval, 3.6-19.4), P

Original languageEnglish
Pages (from-to)777-784
Number of pages8
JournalCirculation: Arrhythmia and Electrophysiology
Issue number4
Publication statusPublished - Aug 22 2015


  • arrhythmias
  • Brugada syndrome
  • cardiac
  • electrophysiology
  • prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)


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