Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma

Marco Colleoni, Mariarosa Biasin, Luca Boni, Patrizia Nelli, Francesca Pancheri, Giovanni Vicario, Gigliola Sgarbossa, Giorgio Mastrapasqua, Domenico Infantolino, Paolo Manente

Research output: Contribution to journalArticle

Abstract

Recent studies indicate that evaluation of cell proliferation in malignant tumors may have prognostic value, but limited data are available on its expression in hepatocellular carcinoma. We therefore evaluated the prognostic tool of PCNA antigen expression on paraffin-embedded sections of 54 patients with hepatocellular carcinoma and concomitant cirrhosis. According to the number of positive cells, the PCNA expression ranged between 0.8 and 47%, and was divided into two groups (Group A, PCNA ≤5.5%; Group B, PCNA >5.5%). The two groups of patients were numerically well balanced. Median survival was 16 months for group A and 12 months for group B. According to the Cox multivariate analysis, PCNA expression (P=0.002), TNM stage (P-0.009) and ECOG performance status (P

Original languageEnglish
Pages (from-to)541-545
Number of pages5
JournalInternational Journal of Oncology
Volume9
Issue number3
Publication statusPublished - Sep 1996

Keywords

  • hepatocellular carcinoma
  • PCNA expression
  • prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Colleoni, M., Biasin, M., Boni, L., Nelli, P., Pancheri, F., Vicario, G., Sgarbossa, G., Mastrapasqua, G., Infantolino, D., & Manente, P. (1996). Prognostic value of proliferating cell nuclear antigen (PCNA) expression in unresectable hepatocellular carcinoma. International Journal of Oncology, 9(3), 541-545.