Prognostic value of pulmonary hypertension in patients with chronic interstitial lung disease referred for lung or heart-lung transplantation

S. Harari, G. Simonneau, E. De Juli, F. Brenot, J. Cerrina, P. Colombo, E. Gronda, E. Micallef, F. Parent, P. Dartevelle

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Abstract

Background: The purpose of this study was to identify precise and reliable prognostic parameters in patients affected by serious chronic interstitial lung disease, who were undergoing screening for lung or heart- lung transplantation. Methods: Hemodynamic and respiratory function parameters of 67 patients (43 with idiopathic pulmonary fibrosis, 18 with histiocytosis X, and 6 with lymphangioleiomyomatosis) undergoing clinical screening for lung transplantation. Results: Statistical analysis showed that hemodynamic and respiratory function parameters in patients affected by histiocytosis X and idiopathic pulmonary fibrosis were not related to survival time. Moreover, the degree of pulmonary hypertension showed no correlation between respiratory function parameters in all the groups of diseases examined. Patients affected with histiocytosis X, even with higher degrees of pulmonary hypertension, had a better survival rate (p <0.005) compared with patients with idiopathic pulmonary fibrosis. Conclusions: Hemodynamic and respiratory parameters obtained during the clinical screening for lung transplantation do not predict survival and cannot bc used as prognostic indicators.

Original languageEnglish
Pages (from-to)460-463
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume16
Issue number4
Publication statusPublished - 1997

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Harari, S., Simonneau, G., De Juli, E., Brenot, F., Cerrina, J., Colombo, P., Gronda, E., Micallef, E., Parent, F., & Dartevelle, P. (1997). Prognostic value of pulmonary hypertension in patients with chronic interstitial lung disease referred for lung or heart-lung transplantation. Journal of Heart and Lung Transplantation, 16(4), 460-463.