TY - JOUR
T1 - Prognostic Value of Resection Margins in Supracricoid Laryngectomy
AU - Gallo, Andrea
AU - Manciocco, Valentina
AU - Tropiano, Maria Luisa
AU - Simonelli, Marilia
AU - Marvaso, Vincenzo
AU - D'Arcangelo, Enzo
AU - De Vincentiis, Marco
PY - 2004/4
Y1 - 2004/4
N2 - Objectives: The objective was to assess the prognostic value of surgical margin involvement in patients treated for squamous cell carcinoma of the larynx. Study Design: Retrospective study. Methods: A review was made of 253 patients treated with supracricoid laryngectomy between 1984 and 2001. A histopathological study on the surgical resection margins was performed in all cases. The incidence of local recurrence was correlated with the histological features of resection margins. Results: Forty patients (15.8%) were identified as having positive margins: 29 had invasive carcinoma and 11 had dysplastic lesions. The remaining 213 patients (84.2%) had negative margins. Subsequent follow-up showed that 19 of 253 patients developed local recurrence and 3 patients developed regional recurrence. Nine of these patients had positive resection margins (six with invasive carcinoma and three with dysplastic lesions), and 10 had negative resection margins. Overall survival at 3 years was significantly higher for patients without recurrence than for patients with local or regional failure (89.9% vs. 45.5% [P <.05]). Conclusion: According to results of the study, patients with positive resection margins developed local recurrence more frequently than those with clear resection margins (P <.05).
AB - Objectives: The objective was to assess the prognostic value of surgical margin involvement in patients treated for squamous cell carcinoma of the larynx. Study Design: Retrospective study. Methods: A review was made of 253 patients treated with supracricoid laryngectomy between 1984 and 2001. A histopathological study on the surgical resection margins was performed in all cases. The incidence of local recurrence was correlated with the histological features of resection margins. Results: Forty patients (15.8%) were identified as having positive margins: 29 had invasive carcinoma and 11 had dysplastic lesions. The remaining 213 patients (84.2%) had negative margins. Subsequent follow-up showed that 19 of 253 patients developed local recurrence and 3 patients developed regional recurrence. Nine of these patients had positive resection margins (six with invasive carcinoma and three with dysplastic lesions), and 10 had negative resection margins. Overall survival at 3 years was significantly higher for patients without recurrence than for patients with local or regional failure (89.9% vs. 45.5% [P <.05]). Conclusion: According to results of the study, patients with positive resection margins developed local recurrence more frequently than those with clear resection margins (P <.05).
KW - Laryngeal cancer
KW - Laryngeal recurrences
KW - Prognosis
KW - Resection margins
KW - Supracricoid laryngectomy
UR - http://www.scopus.com/inward/record.url?scp=1842557942&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842557942&partnerID=8YFLogxK
U2 - 10.1097/00005537-200404000-00005
DO - 10.1097/00005537-200404000-00005
M3 - Article
C2 - 15064613
AN - SCOPUS:1842557942
VL - 114
SP - 616
EP - 621
JO - Laryngoscope
JF - Laryngoscope
SN - 0023-852X
IS - 4
ER -