Prognostic value of serum and tumor tissue CA 72-4 content in gastric cancer

S. Aloe, R. D'Alessandro, A. Spila, P. Ferroni, S. Basili, R. Palmirotta, M. Carlini, F. Graziano, R. Mancini, S. Mariotti, M. Cosimelli, M. Roselli, Fiorella Guadagni

Research output: Contribution to journalArticle

Abstract

To date no general agreement has been reached regarding the prognostic significance of CEA, CA 19-9 and CA 72-4 as serum markers in gastric cancer, and only scattered information is available on the predictive value of marker expression in tumor tissue. Therefore, a longitudinal study was designed to analyze the presurgical serum and tumor tissue content of CA 72-4, CEA and CA 19-9 in 166 patients at different stages of gastric cancer, and to evaluate the possible correlation with clinicopathological features in respect to prognostic information on relapse-free survival. The results obtained showed that 48.4% of patients with tumor recurrence had positive presurgical CA 72-4 levels compared to approximately 24% of patients who remained free of disease. Furthermore, the median presurgical serum CA 72-4 levels were significantly elevated in relapsing patients. Serosa and lymph node involvement as well as positive presurgical serum CA 72-4 levels had independent prognostic value in predicting recurrence. A significant association between disease-free survival and lymph node involvement, depth of invasion and tumor tissue content of CA 72-4 was also demonstrated. We may therefore conclude that CA 72-4 antigen can be considered the marker of choice in the follow-up of gastric cancer patients and may be used as a prognostic indicator of relapse.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalInternational Journal of Biological Markers
Volume18
Issue number1
Publication statusPublished - Jan 2003

Keywords

  • Gastric cancer
  • Prognosis
  • Serum tumor markers
  • Tumor issue antigen content

ASJC Scopus subject areas

  • Immunology
  • Biochemistry

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    Aloe, S., D'Alessandro, R., Spila, A., Ferroni, P., Basili, S., Palmirotta, R., Carlini, M., Graziano, F., Mancini, R., Mariotti, S., Cosimelli, M., Roselli, M., & Guadagni, F. (2003). Prognostic value of serum and tumor tissue CA 72-4 content in gastric cancer. International Journal of Biological Markers, 18(1), 21-27.