Prognostic value of signal-averaged electrocardiogram in Chagas disease

Antonio Luiz Pinho Ribeiro, Paulo Sérgio Cavalvanti, Federico Lombardi, Maria Do Carmo Pereira Nunes, Márcio Vinícius Lins Barros, Manoel Otávio Da Costa Rocha

Research output: Contribution to journalArticlepeer-review


SAECG in Chagas Disease. Background: The value of signal-averaged ECG (SAECG) in the risk stratification of Chagas disease (ChD), a potentially lethal illness prevalent in Latin America, remains controversial. The aim of this prospective longitudinal study was to determine the prognostic value of SAECG in ChD, using multivariate models with other established prognostic predictors, and to develop a simple prediction risk score. Methods: The study enrolled 184 ambulatory ChD patients (107 men; age: 48 ± 12 years) in sinus rhythm and without other systemic diseases. All patients underwent comprehensive evaluation that included clinical examination, ECG, chest X-ray, 24-hour Holter monitoring, echocardiogram, stress testing, and time domain SAECG. Individual medical therapy was adjusted according to a standardized treatment regimen. The association of potential risk factors obtained by noninvasive evaluation and death was tested by Cox proportional-hazards analysis. Results: During mean follow-up time of 74 ± 17 months, 13 patients died. Three independent prognostic factors were identified: left ventricular ejection fraction 150 ms) filtered QRS complex (HR = 4.3, P = 0.035). A prognostic score developed considering the number of risk factors of each patient had an excellent performance in predicting death (c statistic: 0.92). Conclusions: Prolonged filtered QRS duration obtained by SAECG is an independent predictor of death in ChD. A prediction score including three risk factors, depressed left ventricular ejection fraction, ventricular tachycardia and prolonged filtered QRS complex, has shown to be useful for stratifying risk categories in ChD.

Original languageEnglish
Pages (from-to)502-509
Number of pages8
JournalJournal of Cardiovascular Electrophysiology
Issue number5
Publication statusPublished - May 2008


  • Chagas disease
  • Prognosis
  • Signal averaged electrocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology


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