Prognostic value of some laboratory parameters in a group of intravenous drug users in the early stages of HIV infection

Lorenzo Cirasino, Angelo Caroli, Marcello Imbriani, Antonio Prete, Alessandra Ferrario, Aldo Silvani

Research output: Contribution to journalArticle

Abstract

During a 5 year follow-up we found significantly reduced survival for non-accidental deaths in 37 intravenous drug users (IVUDs) in the early stages of HIV infection when compared with 32 HIV-negative IVUDs (p = 0.017). Moreover, in HIV-positive subjects, survival was significantly reduced for those groups which at the beginning of the follow-up showed the following values: circulating CD4+ lymphocytes <250/mmc (p = 0.007), CD4+/CD8+ ratio <0.5 (p = 0.027), serum albumin <4.13 g/dl (p = 0.045). IgA ≥ 2.5 g/L (p = 0.043), IgM <1.8 g/L (p = 0.041) and platelet count <130 x 1,000/mmc (p = 0.038). In HIV positive patients, the value of 250 units/mmc for the circulating CD4+ lymphocytes still remained the most predictive parameter of increased mortality for disease at 5 years, even following investigations conducted with other cut-offs. Relationships existing at the beginning of the follow-up between circulating CD4+ lymphocytes and other prognostic parameters suggest that IgA (r = -0.34; p = 0.04), serum albumin (r = 0.33; p = 0.05), and CD4+/CD8+ ratio (r = 0.72; p = 0.0001), but not IgM (r = 0.25; N.S.) and platelets (r = 0.07; N.S.), are dependent variables of shortened survival.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalRecenti Progressi in Medicina
Volume87
Issue number1
Publication statusPublished - Jan 1996

Keywords

  • albumin
  • CD4+ lymphocytes
  • CD4+/CD8+ ratio
  • HIV
  • IgA
  • IgM
  • platelets
  • survival

ASJC Scopus subject areas

  • Medicine(all)

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