Prognostic value of stromal and epithelial periostin expression in human prostate cancer: Correlation with clinical pathological features and the risk of biochemical relapse or death

Pier Vitale Nuzzo, Alessandra Rubagotti, Linda Zinoli, Francesco Ricci, Sandra Salvi, Simona Boccardo, Francesco Boccardo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The purpose of the present study was to evaluate the prognostic value of POSTN expression following prostatectomy.Methods: Periostin (POSTN) expression in prostate cancer (PCa) and in normal specimens was evaluated in 90 patients by an immuno-reactive score(IRS) based on the intensity of immunostaining and on the quantity of stained cells. The t-test was applied to compare IRS values in cancer specimens to values in normal specimens. Pearson's test was used to correlate POSTN expression to clinical pathologic features. PSA progression-free and survival curves were constructed by the Kaplan-Meier method and compared using the log-rank test. Multi-parametric models were constructed according to the Cox technique adding all the covariates predicting for either PSA progression or death into the models after univariate analysis.Results: Both stromal and epithelial POSTN expression were significantly increased in tumor tissues. In particular, we found stromal expression to be significantly higher than epithelial expression as compared to normal tissues (p

Original languageEnglish
Article number625
JournalBMC Cancer
Volume12
DOIs
Publication statusPublished - Dec 28 2012

Keywords

  • Biomarkers
  • Extracellular matrix proteins
  • Human
  • POSTN protein
  • Prognosis
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Fingerprint Dive into the research topics of 'Prognostic value of stromal and epithelial periostin expression in human prostate cancer: Correlation with clinical pathological features and the risk of biochemical relapse or death'. Together they form a unique fingerprint.

Cite this