Abstract
The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.
| Original language | English |
|---|---|
| Pages (from-to) | 15-20 |
| Number of pages | 6 |
| Journal | American Journal of Nephrology |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Nephrology
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Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy. / Zucchelli, P.; Ponticelli, C.; Cagnoli, L.; Aroldi, A.; Beltrandi, E.
In: American Journal of Nephrology, Vol. 8, No. 1, 1988, p. 15-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy
AU - Zucchelli, P.
AU - Ponticelli, C.
AU - Cagnoli, L.
AU - Aroldi, A.
AU - Beltrandi, E.
PY - 1988
Y1 - 1988
N2 - The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.
AB - The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.
UR - http://www.scopus.com/inward/record.url?scp=0023946080&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023946080&partnerID=8YFLogxK
M3 - Article
C2 - 2967032
AN - SCOPUS:0023946080
VL - 8
SP - 15
EP - 20
JO - American Journal of Nephrology
JF - American Journal of Nephrology
SN - 0250-8095
IS - 1
ER -