Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy

P. Zucchelli, C. Ponticelli, L. Cagnoli, A. Aroldi, E. Beltrandi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalAmerican Journal of Nephrology
Volume8
Issue number1
Publication statusPublished - 1988

Fingerprint

Membranous Glomerulonephritis
T-Lymphocyte Subsets
Chlorambucil
Lymphocyte Subsets
Methylprednisolone
Nephrotic Syndrome
Proteinuria
Cellular Immunity
Appointments and Schedules
Therapeutics
Monoclonal Antibodies

ASJC Scopus subject areas

  • Nephrology

Cite this

Zucchelli, P., Ponticelli, C., Cagnoli, L., Aroldi, A., & Beltrandi, E. (1988). Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy. American Journal of Nephrology, 8(1), 15-20.

Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy. / Zucchelli, P.; Ponticelli, C.; Cagnoli, L.; Aroldi, A.; Beltrandi, E.

In: American Journal of Nephrology, Vol. 8, No. 1, 1988, p. 15-20.

Research output: Contribution to journalArticle

Zucchelli, P, Ponticelli, C, Cagnoli, L, Aroldi, A & Beltrandi, E 1988, 'Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy', American Journal of Nephrology, vol. 8, no. 1, pp. 15-20.
Zucchelli P, Ponticelli C, Cagnoli L, Aroldi A, Beltrandi E. Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy. American Journal of Nephrology. 1988;8(1):15-20.
Zucchelli, P. ; Ponticelli, C. ; Cagnoli, L. ; Aroldi, A. ; Beltrandi, E. / Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy. In: American Journal of Nephrology. 1988 ; Vol. 8, No. 1. pp. 15-20.
@article{95380067b4bd40899e3d1c3f38483a19,
title = "Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy",
abstract = "The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.",
author = "P. Zucchelli and C. Ponticelli and L. Cagnoli and A. Aroldi and E. Beltrandi",
year = "1988",
language = "English",
volume = "8",
pages = "15--20",
journal = "American Journal of Nephrology",
issn = "0250-8095",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy

AU - Zucchelli, P.

AU - Ponticelli, C.

AU - Cagnoli, L.

AU - Aroldi, A.

AU - Beltrandi, E.

PY - 1988

Y1 - 1988

N2 - The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.

AB - The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.

UR - http://www.scopus.com/inward/record.url?scp=0023946080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023946080&partnerID=8YFLogxK

M3 - Article

C2 - 2967032

AN - SCOPUS:0023946080

VL - 8

SP - 15

EP - 20

JO - American Journal of Nephrology

JF - American Journal of Nephrology

SN - 0250-8095

IS - 1

ER -