Prognostic value of T lymphocyte subset ratio in idiopathic membranous nephropathy

P. Zucchelli, C. Ponticelli, L. Cagnoli, A. Aroldi, E. Beltrandi

Research output: Contribution to journalArticlepeer-review

Abstract

The behavior of T lymphocyte subsets was studied in 39 Italian patients with nephrotic syndrome due to idiopathic membranous nephropathy. They took part in a long-term prospective and randomized therapeutic trial based on the 6-month administration of methylprednisolone and chlorambucil. The lymphocyte subsets were evaluated by monoclonal antibodies at the beginning of the trial and at the end of the follow-up period in 23 treated and in 16 untreated patients. Our data seem to suggest that a higher helper-inducer/suppressor-cytotoxic cell ratio before therapy may be a good prognostic index of improved proteinuria. Moreover, the therapeutic schedule does not seem to induce a long-lasting abnormality in cellular immunity.

Original languageEnglish
Pages (from-to)15-20
Number of pages6
JournalAmerican Journal of Nephrology
Volume8
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Nephrology

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