Prognostic value of the activated partial thromboplastin time after orthotopic liver transplantation - A prospective study

I. Martinelli, M. Moia, B. Gridelli, D. Panzeri, M. Langer, P. M. Mannucei

Research output: Contribution to journalArticle

Abstract

In this prospective study, we evaluated the predictive value of activated partial thromboplastin time on day 8 post transplantation for event-free survival in patients who had had orthotopic liver transplants; both death and retransplantation within 6 months were the events considered. In a 4-year period, 109 patients had orthotopic liver transplants in our hospital, and 104 were eligible for the study since they survived and were not given new transplants within 8 days. The activated partial thromboplastin time was significantly longer in patients who survived event-free for less than 6 months than in those with longer event-free survivals. Kaplan-Meier curves showed that patients with normal activated partial thromboplastin times were nine times more likely to survive more than 6 months without events than patients with prolonged values. The positive predictive value of activated partial thromboplastin time for event-free survival was 88% and the negative predictive value was 54%, indicating that the test is useful for predicting patient outcome. We suggest that activated partial thromboplastin time be performed on day 8 post transplantation to predict the medium-term event-free survival.

Original languageEnglish
Pages (from-to)220-222
Number of pages3
JournalInternational Journal of Clinical & Laboratory Research
Volume24
Issue number4
DOIs
Publication statusPublished - Dec 1994

Keywords

  • Activated partial thromboplastin time
  • Hemostasis parameters
  • Liver transplantation

ASJC Scopus subject areas

  • Clinical Biochemistry

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