Prognostic value of the acute-to-chronic glycemic ratio at admission in acute myocardial infarction: A prospective study

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Abstract

© 2018 by the American Diabetes Association. OBJECTIVE Acute hyperglycemia is a powerful predictor of poor prognosis in acute myocardial infarction (AMI), particularly in patients without diabetes. This emphasizes the importance of an acute glycemic rise rather than glycemia level at admission alone.We investigated in AMI whether the combined evaluation of acute and chronic glycemic levels, as compared with admission glycemia alone, may have a better prognostic value. RESEARCH DESIGN AND METHODS We prospectively measured admission glycemia and estimated average chronic glucose levels (mg/dL) by the following formula: [(28.7×glycosylated hemoglobin %)-46.7], and calculated the acute-to-chronic (A/C) glycemic ratio in 1,553 consecutive AMI patients (mean±SD age 67±13 years). The primary end pointwas the combination of in-hospital mortality, acute pulmonary edema, and cardiogenic shock. RESULTS The primary end point rate increased in parallel with A/C glycemic ratio tertiles (5%, 8%, and 20%, respectively; P for trend
Original languageEnglish
Pages (from-to)847-853
Number of pages7
JournalDiabetes Care
Volume41
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

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Myocardial Infarction
Prospective Studies
Cardiogenic Shock
Pulmonary Edema
Hospital Mortality
Hyperglycemia
Hemoglobins
Glucose

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title = "Prognostic value of the acute-to-chronic glycemic ratio at admission in acute myocardial infarction: A prospective study",
abstract = "{\circledC} 2018 by the American Diabetes Association. OBJECTIVE Acute hyperglycemia is a powerful predictor of poor prognosis in acute myocardial infarction (AMI), particularly in patients without diabetes. This emphasizes the importance of an acute glycemic rise rather than glycemia level at admission alone.We investigated in AMI whether the combined evaluation of acute and chronic glycemic levels, as compared with admission glycemia alone, may have a better prognostic value. RESEARCH DESIGN AND METHODS We prospectively measured admission glycemia and estimated average chronic glucose levels (mg/dL) by the following formula: [(28.7×glycosylated hemoglobin {\%})-46.7], and calculated the acute-to-chronic (A/C) glycemic ratio in 1,553 consecutive AMI patients (mean±SD age 67±13 years). The primary end pointwas the combination of in-hospital mortality, acute pulmonary edema, and cardiogenic shock. RESULTS The primary end point rate increased in parallel with A/C glycemic ratio tertiles (5{\%}, 8{\%}, and 20{\%}, respectively; P for trend",
author = "Marenzi, {Giancarlo Silvio} and Nicola Cosentino and Valentina Milazzo and {De Metrio}, Monica and Mara Rubino and Jeness Campodonico and Marco Moltrasio and Ivana Marana and mauro grazi and Alice Bonomi and Fabrizio Veglia and roberto manfrini and Antonio Bartorelli",
year = "2018",
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doi = "10.2337/dc17-1732",
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pages = "847--853",
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TY - JOUR

T1 - Prognostic value of the acute-to-chronic glycemic ratio at admission in acute myocardial infarction: A prospective study

AU - Marenzi, Giancarlo Silvio

AU - Cosentino, Nicola

AU - Milazzo, Valentina

AU - De Metrio, Monica

AU - Rubino, Mara

AU - Campodonico, Jeness

AU - Moltrasio, Marco

AU - Marana, Ivana

AU - grazi, mauro

AU - Bonomi, Alice

AU - Veglia, Fabrizio

AU - manfrini, roberto

AU - Bartorelli, Antonio

PY - 2018/4/1

Y1 - 2018/4/1

N2 - © 2018 by the American Diabetes Association. OBJECTIVE Acute hyperglycemia is a powerful predictor of poor prognosis in acute myocardial infarction (AMI), particularly in patients without diabetes. This emphasizes the importance of an acute glycemic rise rather than glycemia level at admission alone.We investigated in AMI whether the combined evaluation of acute and chronic glycemic levels, as compared with admission glycemia alone, may have a better prognostic value. RESEARCH DESIGN AND METHODS We prospectively measured admission glycemia and estimated average chronic glucose levels (mg/dL) by the following formula: [(28.7×glycosylated hemoglobin %)-46.7], and calculated the acute-to-chronic (A/C) glycemic ratio in 1,553 consecutive AMI patients (mean±SD age 67±13 years). The primary end pointwas the combination of in-hospital mortality, acute pulmonary edema, and cardiogenic shock. RESULTS The primary end point rate increased in parallel with A/C glycemic ratio tertiles (5%, 8%, and 20%, respectively; P for trend

AB - © 2018 by the American Diabetes Association. OBJECTIVE Acute hyperglycemia is a powerful predictor of poor prognosis in acute myocardial infarction (AMI), particularly in patients without diabetes. This emphasizes the importance of an acute glycemic rise rather than glycemia level at admission alone.We investigated in AMI whether the combined evaluation of acute and chronic glycemic levels, as compared with admission glycemia alone, may have a better prognostic value. RESEARCH DESIGN AND METHODS We prospectively measured admission glycemia and estimated average chronic glucose levels (mg/dL) by the following formula: [(28.7×glycosylated hemoglobin %)-46.7], and calculated the acute-to-chronic (A/C) glycemic ratio in 1,553 consecutive AMI patients (mean±SD age 67±13 years). The primary end pointwas the combination of in-hospital mortality, acute pulmonary edema, and cardiogenic shock. RESULTS The primary end point rate increased in parallel with A/C glycemic ratio tertiles (5%, 8%, and 20%, respectively; P for trend

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