Prognostic value of the immunocytochemical detection of extramural venous invasion in Duke's C colorectal adenocarcinomas

G. Lapertosa, P. Baracchini, E. Fulcheri, R. Tanzi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In postsurgical staging of colorectal adenocarcinomas, it is sometimes difficult to determine the range of possible venous spread. Distinguishing between the extramural veins (especially when the neoplastic embolus takes up the whole lumen and the endothelium cannot be identified) and the smallest extramural lymph nodes (when they are completely replaced by metastatic carcinoma, leaving the capsule alone) is also difficult. This work proposes a more precise definition of true venous invasion to improve histopathologic staging. Immunohistochemical techniques employing commercial antibodies against Factor VIII RAG, with and without enzymatic digestion, and UEA I lectin for residual endothelium detection, were applied, as well as antibodies against vimentin, desmin, and alpha sm-1 actin to detect wall components. The immunohistochemical evaluation of colorectal adenocarcinomas, in particular by anti-alpha sm-1 actin antibodies permitted a reliable morphologic distinction of the true venous invasion. This factor proved to be relevant for survival rate prediction.

Original languageEnglish
Pages (from-to)939-945
Number of pages7
JournalAmerican Journal of Pathology
Volume135
Issue number5
Publication statusPublished - 1989

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Adenocarcinoma
Endothelium
Antibodies
Actins
Desmin
Factor VIII
Vimentin
Embolism
Lectins
Capsules
Digestion
Veins
Lymph Nodes
Carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prognostic value of the immunocytochemical detection of extramural venous invasion in Duke's C colorectal adenocarcinomas. / Lapertosa, G.; Baracchini, P.; Fulcheri, E.; Tanzi, R.

In: American Journal of Pathology, Vol. 135, No. 5, 1989, p. 939-945.

Research output: Contribution to journalArticle

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