TY - JOUR
T1 - Prognostic value of the stromal cell-derived factor 1 3′A mutation in pediatric human immunodeficiency virus type 1 infection
AU - Tresoldi, Eleonora
AU - Romiti, Maria Luisa
AU - Boniotto, Michele
AU - Crovella, Sergio
AU - Salvatori, Francesca
AU - Palomba, Elvia
AU - Pastore, Angela
AU - Cancrini, Caterina
AU - De Martino, Maurizio
AU - Plebani, Anna
AU - Castelli, Guido
AU - Rossi, Paolo
AU - Tovo, Pier Angelo
AU - Amoroso, Antonio
AU - Scarlatti, Gabriella
PY - 2002/3/1
Y1 - 2002/3/1
N2 - A mutation of the sromal cell-derived factor 1 gene (SDF-1 3′A) was shown to protect adults exposed to human immunodeficiency virus type 1 (HIV-1) from infection and to affect HIV disease progression in adults. The presence of this mutation in HIV-1-infected Kenyan children did not predict mother-to-child virus transmission. The SDF-1 3′A polymorphism was studied in 256 HIV-1-infected, 118 HIV-1-exposed but uninfected, and 170 unexposed and uninfected children of Italian origin, and the frequency of SDF-1 3′A heterozygosity and homozygosity in each of the 3 groups was similar. Of the 256 HIV-1-infected children, 194 were regularly followed up and were assigned to groups according to disease progression. The frequency of the SDF-1 3′A allele was substantially lower among children with long-term nonprogression than among children with rapid (P = .0329) or delayed (P = .0375) progression. We show that the presence of the SDF-1 3′A gene correlates with accelerated disease progression in HIV-1-infected children born to seropositive mothers but does not protect against mother-to-child HIV-1 transmission.
AB - A mutation of the sromal cell-derived factor 1 gene (SDF-1 3′A) was shown to protect adults exposed to human immunodeficiency virus type 1 (HIV-1) from infection and to affect HIV disease progression in adults. The presence of this mutation in HIV-1-infected Kenyan children did not predict mother-to-child virus transmission. The SDF-1 3′A polymorphism was studied in 256 HIV-1-infected, 118 HIV-1-exposed but uninfected, and 170 unexposed and uninfected children of Italian origin, and the frequency of SDF-1 3′A heterozygosity and homozygosity in each of the 3 groups was similar. Of the 256 HIV-1-infected children, 194 were regularly followed up and were assigned to groups according to disease progression. The frequency of the SDF-1 3′A allele was substantially lower among children with long-term nonprogression than among children with rapid (P = .0329) or delayed (P = .0375) progression. We show that the presence of the SDF-1 3′A gene correlates with accelerated disease progression in HIV-1-infected children born to seropositive mothers but does not protect against mother-to-child HIV-1 transmission.
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U2 - 10.1086/339004
DO - 10.1086/339004
M3 - Article
C2 - 11865429
AN - SCOPUS:0036499210
VL - 185
SP - 696
EP - 700
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -