Programmed cell death 4 protein in esophageal cancer

Matteo Fassan, Matteo Cagol, Gianmaria Pennelli, Christian Rizzetto, Luciano Giacomelli, Giorgio Battaglia, Giovanni Zaninotto, Ermanno Ancona, Alberto Ruol, Massimo Rugge

Research output: Contribution to journalArticlepeer-review

Abstract

Screening for genes down-regulated in esophageal cancers (Oncomine database) pinpointed programmed cell death 4 (PDCD4) as one of the most consistently involved. PDCD4 is a new putative tumor suppressor gene implicated in cell transformation, tumorigenesis, and invasiveness. Based on such a biological rationale, the aim of the present study was to evaluate the prognostic value of PDCD4 in esophageal cancers. The immunohistochemical expression of PDCD4 protein was assessed in 111 consecutive esophageal cancers (63 adenocarcinomas and 48 squamous cell carcinomas) and paired non-cancerous samples. PDCD4 immunostaining was significantly lower in cancer samples than in non-cancerous mucosa (p

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalOncology Reports
Volume24
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • Esophageal cancer
  • Immunohistochemistry
  • PDCD4
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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