Programmed cell death 4 protein in esophageal cancer

Matteo Fassan; Matteo Cagol; Gianmaria Pennelli; Christian Rizzetto; Luciano Giacomelli; Giorgio Battaglia; Giovanni Zaninotto; Ermanno Ancona; Alberto Ruol; Massimo Rugge

doi:10.3892/or-00000838

Programmed cell death 4 protein in esophageal cancer

Matteo Fassan, Matteo Cagol, Gianmaria Pennelli, Christian Rizzetto, Luciano Giacomelli, Giorgio Battaglia, Giovanni Zaninotto, Ermanno Ancona, Alberto Ruol, Massimo Rugge

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Screening for genes down-regulated in esophageal cancers (Oncomine database) pinpointed programmed cell death 4 (PDCD4) as one of the most consistently involved. PDCD4 is a new putative tumor suppressor gene implicated in cell transformation, tumorigenesis, and invasiveness. Based on such a biological rationale, the aim of the present study was to evaluate the prognostic value of PDCD4 in esophageal cancers. The immunohistochemical expression of PDCD4 protein was assessed in 111 consecutive esophageal cancers (63 adenocarcinomas and 48 squamous cell carcinomas) and paired non-cancerous samples. PDCD4 immunostaining was significantly lower in cancer samples than in non-cancerous mucosa (p

Original language	English
Pages (from-to)	135-139
Number of pages	5
Journal	Oncology Reports
Volume	24
Issue number	1
DOIs	https://doi.org/10.3892/or-00000838
Publication status	Published - 2010

Keywords

Esophageal cancer
Immunohistochemistry
PDCD4
Tumor suppressor gene

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

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AU - Fassan, Matteo

AU - Cagol, Matteo

AU - Pennelli, Gianmaria

AU - Rizzetto, Christian

AU - Giacomelli, Luciano

AU - Battaglia, Giorgio

AU - Zaninotto, Giovanni

AU - Ancona, Ermanno

AU - Ruol, Alberto

AU - Rugge, Massimo

PY - 2010

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N2 - Screening for genes down-regulated in esophageal cancers (Oncomine database) pinpointed programmed cell death 4 (PDCD4) as one of the most consistently involved. PDCD4 is a new putative tumor suppressor gene implicated in cell transformation, tumorigenesis, and invasiveness. Based on such a biological rationale, the aim of the present study was to evaluate the prognostic value of PDCD4 in esophageal cancers. The immunohistochemical expression of PDCD4 protein was assessed in 111 consecutive esophageal cancers (63 adenocarcinomas and 48 squamous cell carcinomas) and paired non-cancerous samples. PDCD4 immunostaining was significantly lower in cancer samples than in non-cancerous mucosa (p

AB - Screening for genes down-regulated in esophageal cancers (Oncomine database) pinpointed programmed cell death 4 (PDCD4) as one of the most consistently involved. PDCD4 is a new putative tumor suppressor gene implicated in cell transformation, tumorigenesis, and invasiveness. Based on such a biological rationale, the aim of the present study was to evaluate the prognostic value of PDCD4 in esophageal cancers. The immunohistochemical expression of PDCD4 protein was assessed in 111 consecutive esophageal cancers (63 adenocarcinomas and 48 squamous cell carcinomas) and paired non-cancerous samples. PDCD4 immunostaining was significantly lower in cancer samples than in non-cancerous mucosa (p

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KW - Immunohistochemistry

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