Programmed cell death of myelin basic protein-specific T lymphocytes is reduced in patients with acute multiple sclerosis

Marina Saresella, Ivana Marventano, Livianna Speciale, Stefania Ruzzante, Daria Trabattoni, Silvia Della Bella, Massimo Filippi, Francesca Fasano, Rosella Cavarretta, Domenico Caputo, Mario Clerici, Pasquale Ferrante

Research output: Contribution to journalArticle

Abstract

We investigated the apoptosis of myelin basic protein (MBP)-specific T lymphocytes in multiple sclerosis (MS) patients with acute (AMS) or stable (SMS) MS by evaluating the expression of apoptosis markers on peripheral cells. Cells of healthy controls (HC) were evaluated as well. Results showed that mitogen-stimulated apoptosis was comparable among patients and controls, whereas MBP-stimulated CD4+ and CD8+ 7-AAD+ and 7-AAD+ Fas+ cell (apoptotic cells) were significantly reduced in AMS patients. A reduction of the apoptotic rate of myelin-specific CD4+ and CD8+ T lymphocytes could be involved in the immune-mediated destruction of the myelin sheath seen in AMS patients.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalJournal of Neuroimmunology
Volume166
Issue number1-2
DOIs
Publication statusPublished - Sep 2005

Keywords

  • Apoptosis
  • Immunology
  • Multiple sclerosis
  • Myelin basic protein
  • T lymphocyte

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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